Antony Y Matthews
Overview
Explore the profile of Antony Y Matthews including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
219
Followers
0
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Recent Articles
1.
Guanizo A, Luong Q, Jayasekara W, de Geus E, Inampudi C, Xue V, et al.
Nat Immunol
. 2024 Nov;
25(12):2259-2269.
PMID: 39572642
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an overall survival rate of ~5%. The transcription factor signal transducer and activator...
2.
Mayall J, Horvat J, Mangan N, Chevalier A, McCarthy H, Hampsey D, et al.
EMBO Mol Med
. 2024 Jan;
16(2):267-293.
PMID: 38263527
The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in...
3.
de Geus E, Volaric J, Matthews A, Mangan N, Chang J, Ooi J, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Oct;
17(2):267-278.
PMID: 37879406
Background & Aims: Type I interferon (T1IFN) signalling is crucial for maintaining intestinal homeostasis. We previously found that the novel T1IFN, IFNε, is highly expressed by epithelial cells of the...
4.
Marks Z, Campbell N, Mangan N, Vandenberg C, Gearing L, Matthews A, et al.
Nature
. 2023 Aug;
620(7976):1063-1070.
PMID: 37587335
High-grade serous ovarian cancers have low survival rates because of their late presentation with extensive peritoneal metastases and frequent chemoresistance, and require new treatments guided by novel insights into pathogenesis....
5.
de Weerd N, Ogungbola O, Liu X, Matthews A, Ismail A, Vivian J, et al.
J Interferon Cytokine Res
. 2023 Jul;
43(9):403-413.
PMID: 37499093
Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also modulate immune responses by acting through a heterodimeric receptor composed of the specific and limited expressed IFN-λR1 chain...
6.
Salmon J, Todorovski I, Stanley K, Bruedigam C, Kearney C, Martelotto L, et al.
Cancer Discov
. 2022 Mar;
12(6):1560-1579.
PMID: 35311997
Significance: We demonstrate that HDACis induce terminal differentiation of AML through epigenetic remodeling of pDCs, resulting in production of type I IFN that is important for the therapeutic effects of...
7.
Zhang G, deWeerd N, Stifter S, Liu L, Zhou B, Wang W, et al.
Nat Commun
. 2018 Jan;
9(1):85.
PMID: 29311663
Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. However, the precise role of type I IFN...
8.
Stifter S, Matthews A, Mangan N, Fung K, Drew A, Tate M, et al.
J Biol Chem
. 2017 Dec;
293(9):3168-3179.
PMID: 29187603
The type I interferons (IFNs) are a family of cytokines with diverse biological activities, including antiviral, antiproliferative, and immunoregulatory functions. The discovery of the hormonally regulated, constitutively expressed IFNϵ has...
9.
de Weerd N, Matthews A, Pattie P, Bourke N, Lim S, Vivian J, et al.
J Biol Chem
. 2017 Mar;
292(18):7554-7565.
PMID: 28289093
The interaction of IFN-β with its receptor IFNAR1 (interferon α/β receptor subunit 1) is vital for host-protective anti-viral and anti-proliferative responses, but signaling via this interaction can be detrimental if...
10.
Garcia-Minambres A, Eid S, Mangan N, Pade C, Lim S, Matthews A, et al.
Immunol Cell Biol
. 2017 Jan;
95(5):478-483.
PMID: 28045025
Interferon epsilon (IFNɛ) is a type I IFN that is expressed constitutively in the female reproductive tract (FRT), and contributes to protection in models of sexually transmitted infections. Using multiple...