Peter J Crack
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Explore the profile of Peter J Crack including associated specialties, affiliations and a list of published articles.
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67
Citations
4215
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Recent Articles
1.
Venkatraman R, Balka K, Wong W, Sivamani J, Magill Z, Tullett K, et al.
iScience
. 2024 Sep;
27(9):110693.
PMID: 39262777
The cGAS-STING pathway responds to cytosolic DNA to elicit host immunity to infection. The activation of stimulator of interferon genes (STING) can trigger a number of critical cellular responses including...
2.
Fryer A, Abdullah A, Mobilio F, Jobling A, Moore Z, de Veer M, et al.
Br J Pharmacol
. 2024 May;
181(17):3118-3135.
PMID: 38710660
Background And Purpose: Traumatic brain injury (TBI) remains a major public health concern worldwide with unmet effective treatment. Stimulator of interferon genes (STING) and its downstream type-I interferon (IFN) signalling...
3.
Mirzaei S, Kulkarni K, Zhou K, Crack P, Aguilar M, Finkelstein D, et al.
ACS Chem Neurosci
. 2021 Oct;
12(22):4224-4235.
PMID: 34634903
Parkinson's disease (PD) is a progressive neurological disorder, in which dopaminergic midbrain neurons degenerate, leading to dopamine depletion that is associated with neuronal death. In this Review, we initially describe...
4.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
5.
Fryer A, Abdullah A, Taylor J, Crack P
Front Neurosci
. 2021 Feb;
15:621501.
PMID: 33633536
Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of...
6.
Abdullah A, Mobilio F, Crack P, Taylor J
Int J Mol Sci
. 2020 Sep;
21(19).
PMID: 32992769
Stimulator of interferon genes (STING)-mediated type-I interferon signaling is a well characterized instigator of the innate immune response following bacterial or viral infections in the periphery. Emerging evidence has recently...
7.
Matta S, Moore Z, Walker F, Hill-Yardin E, Crack P
Sci Rep
. 2020 Sep;
10(1):14492.
PMID: 32879325
Autism Spectrum Disorder (ASD; autism) is a neurodevelopmental disorder characterised by deficits in social communication, and restricted and/or repetitive behaviours. While the precise pathophysiologies are unclear, increasing evidence supports a...
8.
Moore Z, Mobilio F, Walker F, Taylor J, Crack P
Sci Rep
. 2020 Feb;
10(1):3153.
PMID: 32081950
Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines....
9.
Inampudi C, Ciccotosto G, Cappai R, Crack P
J Neurotrauma
. 2020 Feb;
37(5):706-723.
PMID: 32027210
Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, due in part to the complexity of the injury pathology and...
10.
Motamed S, Del Borgo M, Zhou K, Kulkarni K, Crack P, Merson T, et al.
Front Bioeng Biotechnol
. 2019 Dec;
7:315.
PMID: 31788470
Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migrate long distances and engraft. To overcome these problems,...