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San S Lim

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Articles 8
Citations 92
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Recent Articles
1.
Marks Z, Campbell N, Mangan N, Vandenberg C, Gearing L, Matthews A, et al.
Nature . 2023 Aug; 620(7976):1063-1070. PMID: 37587335
High-grade serous ovarian cancers have low survival rates because of their late presentation with extensive peritoneal metastases and frequent chemoresistance, and require new treatments guided by novel insights into pathogenesis....
2.
de Weerd N, Ogungbola O, Liu X, Matthews A, Ismail A, Vivian J, et al.
J Interferon Cytokine Res . 2023 Jul; 43(9):403-413. PMID: 37499093
Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also modulate immune responses by acting through a heterodimeric receptor composed of the specific and limited expressed IFN-λR1 chain...
3.
Coldbeck-Shackley R, Romeo O, Rosli S, Gearing L, Gould J, Lim S, et al.
PLoS Pathog . 2023 Mar; 19(3):e1010843. PMID: 36897927
The immunological surveillance factors controlling vulnerability of the female reproductive tract (FRT) to sexually transmitted viral infections are not well understood. Interferon-epsilon (IFNɛ) is a distinct, immunoregulatory type-I IFN that...
4.
Bourke N, Achilles S, Huang S, Cumming H, Lim S, Papageorgiou I, et al.
JCI Insight . 2022 Jul; 7(18). PMID: 35862222
Although published studies have demonstrated that IFN-ε has a crucial role in regulating protective immunity in the mouse female reproductive tract, expression and regulation of IFN-ε in the human female...
5.
de Weerd N, Vivian J, Lim S, Huang S, Hertzog P
J Leukoc Biol . 2021 Jan; 108(3):909-924. PMID: 33448473
The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind their cognate receptors, IFNα/β receptor (IFNAR)1 and IFNAR2. These signals contribute to many aspects...
6.
Marks Z, Campbell N, deWeerd N, Lim S, Gearing L, Bourke N, et al.
Semin Immunol . 2019 Nov; 43:101328. PMID: 31734130
Interferon epsilon (IFNε) is a type I IFN with unusual patterns of expression and therefore, function. It is constitutively expressed by reproductive tract epithelium and regulated by hormones during estrus...
7.
de Weerd N, Matthews A, Pattie P, Bourke N, Lim S, Vivian J, et al.
J Biol Chem . 2017 Mar; 292(18):7554-7565. PMID: 28289093
The interaction of IFN-β with its receptor IFNAR1 (interferon α/β receptor subunit 1) is vital for host-protective anti-viral and anti-proliferative responses, but signaling via this interaction can be detrimental if...
8.
Garcia-Minambres A, Eid S, Mangan N, Pade C, Lim S, Matthews A, et al.
Immunol Cell Biol . 2017 Jan; 95(5):478-483. PMID: 28045025
Interferon epsilon (IFNɛ) is a type I IFN that is expressed constitutively in the female reproductive tract (FRT), and contributes to protection in models of sexually transmitted infections. Using multiple...