Patrick P L Lam
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Explore the profile of Patrick P L Lam including associated specialties, affiliations and a list of published articles.
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13
Citations
349
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Recent Articles
1.
Lam P, Ohno M, Dolai S, He Y, Qin T, Liang T, et al.
Diabetes
. 2013 Feb;
62(7):2416-28.
PMID: 23423569
Sec1/Munc18 proteins facilitate the formation of trans-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes that mediate fusion of secretory granule (SG) with plasma membrane (PM). The capacity of pancreatic β-cells...
2.
Zhu D, Zhang Y, Lam P, Dolai S, Liu Y, Cai E, et al.
Cell Metab
. 2012 Jul;
16(2):238-49.
PMID: 22841572
Optimal insulin secretion required to maintain glucose homeostasis is the summation of total pancreatic islet β cell mass and intrinsic secretory capacity of individual β cells, which are regulated by...
3.
Dolai S, Liang T, Lam P, Fernandez N, Chidambaram S, Gaisano H
Gastroenterology
. 2012 Jun;
143(3):832-843.e7.
PMID: 22710192
Background & Aims: During development of alcoholic pancreatitis, oxidative (acetaldehyde) and nonoxidative metabolites (ethyl palmitate, ethyl oleate), rather than ethanol itself, mediate toxic injury. Exposure of pancreatic acini to ethanol...
4.
Choi D, Radziszewska A, Schroer S, Liadis N, Liu Y, Zhang Y, et al.
Am J Physiol Endocrinol Metab
. 2009 Sep;
297(6):E1304-12.
PMID: 19755672
Fas/Fas ligand belongs to the tumor necrosis factor superfamily of receptors/ligands and is best known for its role in apoptosis. However, recent evidence supports its role in other cellular responses,...
5.
Zhang Y, Kang Y, Chang N, Lam P, Liu Y, Olkkonen V, et al.
J Biol Chem
. 2009 Jun;
284(31):20840-7.
PMID: 19487699
Cab45b is a cytosolic Ca(2+)-binding protein reported to regulate zymogen secretion in pancreatic acini. We now show that Cab45b is also expressed in pancreatic islet beta-cells and interacts there with...
6.
Webster N, Searle G, Lam P, Huang Y, Riedel M, Harb G, et al.
Endocrinology
. 2008 Mar;
149(7):3679-87.
PMID: 18372336
Closure of pancreatic beta-cell ATP-sensitive potassium (K(ATP)) channels links glucose metabolism to electrical activity and insulin secretion. It is now known that saturated, but not polyunsaturated, long-chain acyl-coenyzme A esters...
7.
Lam P, Cosen Binker L, Lugea A, Pandol S, Gaisano H
Traffic
. 2007 Apr;
8(5):605-17.
PMID: 17451559
The molecular mechanism of clinical alcohol-induced pancreatitis remains vague. We had reported that experimental high-dose cholecystokinin (CCK)-induced pancreatitis is in part because of excessive aberrant basolateral exocytosis. High-dose CCK caused...
8.
Lam P, Hyvarinen K, Kauppi M, Cosen-Binker L, Laitinen S, Keranen S, et al.
Mol Biol Cell
. 2007 Apr;
18(7):2473-80.
PMID: 17442889
We identified in a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 as an interaction partner of Munc18b. Although the full-length Cab45 resides in Golgi lumen, we characterize a cytosolic...
9.
Cosen-Binker L, Lam P, Binker M, Gaisano H
Gastroenterology
. 2007 Apr;
132(4):1527-45.
PMID: 17408632
Background & Aims: Acute or chronic alcohol treatment does little to the exocrine pancreas but predisposes the pancreas to postprandial cholinergic stimulation that triggers cellular events leading to pancreatitis. This...
10.
Cosen-Binker L, Lam P, Binker M, Reeve J, Pandol S, Gaisano H
J Biol Chem
. 2007 Feb;
282(17):13047-58.
PMID: 17324928
The pancreatic acinus is the functional unit of the exocrine pancreas whose role is to secrete zymogens into the gut lumen for food digestion via apical exocytosis. We previously reported...