Alpha 2.0
Login Register
» Authors » Patrick Cullen

Patrick Cullen

Explore the profile of Patrick Cullen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 23
Citations 394
Followers 0
Related Specialties
Biochemistry
Chemistry
Neurology
Top 10 Co-Authors
Norm Allaire
Thomas M Carlile
Baohong Zhang
Stefan Hamann
Michael Mingueneau
Taylor L Reynolds
Eris Bame
Thomas Carlile
Ravi Challa
Fergal Casey
Published In
Bioorg Med Chem
Gene Ther
Phys Chem Chem Phys
Chem Biol Drug Des
Immunology
Affiliations
Soon will be listed here.
Recent Articles
1.
Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE
Schroeder A, Loth M, Luo C, Yao S, Yan H, Zhang D, et al.
bioRxiv . 2025 Mar; PMID: 40060412
Recent advances in spatial transcriptomics (ST) technologies have transformed our ability to profile gene expression while retaining the crucial spatial context within tissues. However, existing ST platforms suffer from high...
2.
Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice
Hawley Z, Pardo I, Cao S, Zavodszky M, Casey F, Ferber K, et al.
Mol Ther . 2024 Nov; 33(1):215-234. PMID: 39563026
Dorsal root ganglion (DRG) toxicity has been consistently reported as a potential safety concern after delivery of adeno-associated viruses (AAVs) containing gene-replacement vectors but has yet to be reported for...
3.
Controlling nanocluster growth through nanoconfinement: the effect of the number and nature of metal-organic framework functionalities
King J, Lin Z, Zanca F, Luo H, Zhang L, Cullen P, et al.
Phys Chem Chem Phys . 2024 Sep; 26(38):25021-25028. PMID: 39301657
Controlled nanocluster growth nanoconfinement is an attractive approach as it allows for geometry control and potential surface-chemistry modification simultaneously. However, it is still not a straight-forward method and much of...
4.
Plasma-Assisted Sustainable Nitrogen-to-Ammonia Fixation: Mixed-phase, Synergistic Processes and Mechanisms
Qu Z, Zhou R, Sun J, Gao Y, Li Z, Zhang T, et al.
ChemSusChem . 2023 Nov; 17(6):e202300783. PMID: 37994281
Ammonia plays a crucial role in industry and agriculture worldwide, but traditional industrial ammonia production methods are energy-intensive and negatively impact the environment. Ammonia synthesis using low-temperature plasma technology has...
5.
Efficacy and safety of a SOD1-targeting artificial miRNA delivered by AAV9 in mice are impacted by miRNA scaffold selection
Chen S, Hawley Z, Zavodszky M, Hana S, Ferretti D, Grubor B, et al.
Mol Ther Nucleic Acids . 2023 Nov; 34:102057. PMID: 37928442
Toxic gain-of-function mutations in superoxide dismutase 1 (SOD1) contribute to approximately 2%-3% of all amyotrophic lateral sclerosis (ALS) cases. Artificial microRNAs (amiRs) delivered by adeno-associated virus (AAV) have been proposed...
6.
In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model
Chen Y, Kankel M, Hana S, Lau S, Zavodszky M, McKissick O, et al.
Gene Ther . 2022 Nov; 30(5):443-454. PMID: 36450833
CRISPR-based gene editing technology represents a promising approach to deliver therapies for inherited disorders, including amyotrophic lateral sclerosis (ALS). Toxic gain-of-function superoxide dismutase 1 (SOD1) mutations are responsible for ~20%...
7.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors
Hopkins B, Bame E, Bell N, Bohnert T, Bowden-Verhoek J, Bui M, et al.
Bioorg Med Chem . 2021 Jul; 44:116275. PMID: 34314938
Bruton's tyrosine kinase (BTK) is an essential node on the BCR signaling in B cells, which are clinically validated to play a critical role in B-cell lymphomas and various auto-immune...
8.
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response
Pellerin K, Rubino S, Burns J, Smith B, Mccarl C, Zhu J, et al.
Brain . 2021 Jun; 144(8):2361-2374. PMID: 34145876
Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibody-induced Fc receptor...
9.
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells
Bame E, Tang H, Burns J, Arefayene M, Michelsen K, Ma B, et al.
Clin Transl Immunology . 2021 Jun; 10(6):e1295. PMID: 34141433
Objectives: Bruton's tyrosine kinase (BTK) plays a non-redundant signaling role downstream of the B-cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in...
10.
Benchmarking and optimization of a high-throughput sequencing based method for transgene sequence variant analysis in biotherapeutic cell line development
Groot J, Zhou Y, Marshall E, Cullen P, Carlile T, Lin D, et al.
Biotechnol J . 2021 May; 16(8):e2000548. PMID: 34018310
In recent years, High-Throughput Sequencing (HTS) based methods to detect mutations in biotherapeutic transgene products have become a key quality step deployed during the development of manufacturing cell line clones....