Thomas M Carlile
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Explore the profile of Thomas M Carlile including associated specialties, affiliations and a list of published articles.
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16
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1285
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Recent Articles
1.
Hawley Z, Pardo I, Cao S, Zavodszky M, Casey F, Ferber K, et al.
Mol Ther
. 2024 Nov;
33(1):215-234.
PMID: 39563026
Dorsal root ganglion (DRG) toxicity has been consistently reported as a potential safety concern after delivery of adeno-associated viruses (AAVs) containing gene-replacement vectors but has yet to be reported for...
2.
Chen S, Hawley Z, Zavodszky M, Hana S, Ferretti D, Grubor B, et al.
Mol Ther Nucleic Acids
. 2023 Nov;
34:102057.
PMID: 37928442
Toxic gain-of-function mutations in superoxide dismutase 1 (SOD1) contribute to approximately 2%-3% of all amyotrophic lateral sclerosis (ALS) cases. Artificial microRNAs (amiRs) delivered by adeno-associated virus (AAV) have been proposed...
3.
SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
Nicholatos J, Groot J, Dhokai S, Tran D, Hrdlicka L, Carlile T, et al.
eNeuro
. 2021 Jul;
8(4).
PMID: 34301719
Here, we report the independent discovery and validation of stearoyl-CoA desaturase (SCD) as a modulator of α-synuclein (αSyn)-induced pathology and toxicity in cell-based Parkinson's disease (PD) models. We identified SCD...
4.
Pellerin K, Rubino S, Burns J, Smith B, Mccarl C, Zhu J, et al.
Brain
. 2021 Jun;
144(8):2361-2374.
PMID: 34145876
Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibody-induced Fc receptor...
5.
Bame E, Tang H, Burns J, Arefayene M, Michelsen K, Ma B, et al.
Clin Transl Immunology
. 2021 Jun;
10(6):e1295.
PMID: 34141433
Objectives: Bruton's tyrosine kinase (BTK) plays a non-redundant signaling role downstream of the B-cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in...
6.
Delbridge A, Huh D, Brickelmaier M, Burns J, Roberts C, Challa R, et al.
Front Cell Neurosci
. 2021 Jan;
14:592005.
PMID: 33473245
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their manifold context-dependent contributions to neuroinflammation are only...
7.
Lafaille F, Harschnitz O, Lee Y, Zhang P, Hasek M, Kerner G, et al.
Nat Med
. 2019 Dec;
25(12):1873-1884.
PMID: 31806906
Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is typically sporadic. Inborn errors of TLR3- and DBR1-mediated central nervous system cell-intrinsic immunity can account for forebrain and brainstem HSE, respectively. We report...
8.
Carlile T, Martinez N, Schaening C, Su A, Bell T, Zinshteyn B, et al.
Nat Chem Biol
. 2019 Sep;
15(10):966-974.
PMID: 31477916
Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but...
9.
Stanley S, Gable D, Wagner C, Carlile T, Hanumanthu V, Podlevsky J, et al.
Sci Transl Med
. 2016 Aug;
8(351):351ra107.
PMID: 27510903
Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to represent premature aging phenotypes. At times, they cluster in families, but the genetic basis is not understood. We identified...
10.
Carlile T, Rojas-Duran M, Gilbert W
Curr Protoc Mol Biol
. 2015 Oct;
112:4.25.1-4.25.24.
PMID: 26423590
A diverse array of post-transcriptional modifications is found in RNA molecules from all domains of life. While the locations of RNA modifications are well characterized in abundant noncoding RNAs, modified...