Patricia Chastagner
Overview
Explore the profile of Patricia Chastagner including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
510
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Pinto G, Saenz-de-Santa-Maria I, Chastagner P, Perthame E, Delmas C, Toulas C, et al.
Biochem J
. 2020 Nov;
478(1):21-39.
PMID: 33245115
Glioblastoma (GBM) is the most aggressive brain cancer and its relapse after surgery, chemo and radiotherapy appears to be led by GBM stem cells (GSCs). Also, tumor networking and intercellular...
2.
Chastagner P, Loria F, Vargas J, Tois J, Diamond M, Okafo G, et al.
EMBO Mol Med
. 2020 Nov;
12(12):e12025.
PMID: 33179866
Tau accumulation in the form of neurofibrillary tangles in the brain is a hallmark of tauopathies such as Alzheimer's disease (AD). Tau aggregates accumulate in brain regions in a defined...
3.
Chastagner P, Rubinstein E, Brou C
Sci Signal
. 2017 Jun;
10(483).
PMID: 28611181
The Notch signaling pathway, which is activated by cell-cell contact, is a major regulator of cell fate decisions. Mammalian Notch1 is present at the cell surface as a heterodimer of...
4.
Chastagner P, Brou C
Methods Mol Biol
. 2014 Jul;
1187:87-100.
PMID: 25053483
The Notch receptor and its ligands are cell surface transmembrane proteins that are internalized. Endocytosis and vesicle trafficking play key roles in Notch signaling activation and modulation. In mammalian cultured...
5.
Puca L, Chastagner P, Meas-Yedid V, Israel A, Brou C
J Cell Sci
. 2013 Jul;
126(Pt 19):4457-68.
PMID: 23886940
Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated, notably by maintaining a controlled pool of functional receptor at...
6.
Moretti J, Chastagner P, Liang C, Cohn M, Israel A, Brou C
J Biol Chem
. 2012 Jul;
287(35):29429-41.
PMID: 22778262
Notch signaling is critical for development and adult tissue physiology, controlling cell fate in a context-dependent manner. Upon ligand binding, the transmembrane Notch receptor undergoes two ordered proteolytic cleavages releasing...
7.
Moretti J, Chastagner P, Gastaldello S, Heuss S, Dirac A, Bernards R, et al.
PLoS Biol
. 2010 Dec;
8(11):e1000545.
PMID: 21124883
Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble,...
8.
Chastagner P, Israel A, Brou C
PLoS One
. 2008 Jul;
3(7):e2735.
PMID: 18628966
Background: The regulation of Notch signaling heavily relies on ubiquitination events. Drosophila Su(dx), a member of the HECT family of ubiquitin-ligases, has been described as a negative regulator of Notch...
9.
Pillet A, Juffroy O, Mazard-Pasquier V, Moreau J, Gesbert F, Chastagner P, et al.
Eur Cytokine Netw
. 2008 Feb;
19(1):49-59.
PMID: 18299274
Two types of functional interleukin-2 receptor (IL-2Ralpha/IL-2Rbeta/gammac and IL-2Rbeta/gammac) have already been characterized in humans. Here we describe a new form consisting of IL-2Rbeta/beta homodimers that assemble spontaneously in the...
10.
Chastagner P, Israel A, Brou C
EMBO Rep
. 2006 Oct;
7(11):1147-53.
PMID: 17028573
Deltex (DTX) and AIP4 are the human orthologues of the Drosophila deltex and Suppressor of deltex, which have been genetically described as being antagonistically involved in the Notch signalling pathway....