Julien Moretti
Overview
Explore the profile of Julien Moretti including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
664
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Recent Articles
1.
Zanin-Zhorov A, Chen W, Moretti J, Nyuydzefe M, Zhorov I, Munshi R, et al.
Commun Biol
. 2023 Nov;
6(1):1176.
PMID: 37980369
The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have been implicated in these processes, however the ability of selective...
2.
Moretti J, Jia B, Hutchins Z, Roy S, Yip H, Wu J, et al.
Nat Immunol
. 2022 Apr;
23(5):705-717.
PMID: 35487985
Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent bacteria do not invade the cytosol, their presence in tissues necessitates...
3.
Barbet G, Nair-Gupta P, Schotsaert M, Yeung S, Moretti J, Seyffer F, et al.
Nat Immunol
. 2021 Apr;
22(4):497-509.
PMID: 33790474
Classic major histocompatibility complex class I (MHC-I) presentation relies on shuttling cytosolic peptides into the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). Viruses disable TAP to...
4.
Moretti J, Blander J
J Leukoc Biol
. 2020 Jun;
109(3):561-571.
PMID: 32531835
Inflammasomes are multiprotein complexes that assemble upon detection of danger signals to activate the inflammatory enzyme caspase-1, trigger secretion of the highly proinflammatory cytokine IL-1β, and induce an inflammatory cell...
5.
Tummers B, Mari L, Guy C, Heckmann B, Rodriguez D, Ruhl S, et al.
Immunity
. 2020 May;
52(6):994-1006.e8.
PMID: 32428502
Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and lymphoproliferative (LPR) disease in mice result from abrogated CD95-induced apoptosis. Because caspase-8 mediates CD95 signaling, we...
6.
Moretti J, Blander J
Autophagy
. 2018 May;
14(6):1102-1104.
PMID: 29782215
Phagocytes cope with the threat of living bacteria via detection of vita-PAMPs, a specific class of pathogen-associated molecular patterns (PAMPs) that denotes microbial viability and trigger a commensurate innate response....
7.
Moretti J, Vabret N, Blander J
Methods Mol Biol
. 2017 Nov;
1714:167-190.
PMID: 29177862
The innate immune system directly senses microbial viability via the detection of a special class of viability-associated pathogen-associated molecular patterns (vita-PAMPs), such as prokaryotic messenger RNA. In the case of...
8.
Moretti J, Roy S, Bozec D, Martinez J, Chapman J, Ueberheide B, et al.
Cell
. 2017 Oct;
171(4):809-823.e13.
PMID: 29056340
Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals...
9.
Moretti J, Blander J
J Leukoc Biol
. 2016 Oct;
101(1):77-86.
PMID: 27733577
The innate immune response of phagocytes to microbes has long been known to depend on the core signaling cascades downstream of pattern recognition receptors (PRRs), which lead to expression and...
10.
Dornier E, Coumailleau F, Ottavi J, Moretti J, Boucheix C, Mauduit P, et al.
J Cell Biol
. 2016 May;
213(4):495-6.
PMID: 27185832
No abstract available.