Omar Abdel-Wahab
Overview
Explore the profile of Omar Abdel-Wahab including associated specialties, affiliations and a list of published articles.
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320
Citations
23443
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Recent Articles
1.
Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi S, et al.
Elife
. 2025 Mar;
13.
PMID: 40085681
Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have investigated its role in neurodegenerative processes such as Alzheimer's...
2.
Vicario R, Fragkogianni S, Pokrovskii M, Meyer C, Lopez-Rodrigo E, Hu Y, et al.
Neuron
. 2025 Mar;
PMID: 40081365
Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders associated with mitogen-activated protein (MAP)-kinase-activating mutations and an increased risk of neurodegeneration. We found microglial mutant clones in...
3.
Krishnamoorthy G, Glover A, Untch B, Sigcha-Coello N, Xu B, Vukel D, et al.
J Exp Med
. 2025 Feb;
222(5).
PMID: 39992626
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function RBM10 mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by RBM10 loss showed pro-migratory and RHO/RAC...
4.
Cuibus M, Abdel-Wahab O
J Clin Invest
. 2025 Feb;
135(3).
PMID: 39895629
The precise mechanisms of blood pressure (BP) regulation are not fully elucidated, and understanding BP regulation is crucial for managing hypertension and improving outcomes for cardiovascular disease. In this issue...
5.
Bewersdorf J, Mi X, Lu B, Kuykendall A, Sallman D, Patel M, et al.
Leukemia
. 2025 Jan;
39(3):765-769.
PMID: 39856223
No abstract available.
6.
Scott K, Kojima H, Ropek N, Warren C, Zhang T, Hogg S, et al.
Cell Chem Biol
. 2024 Nov;
32(1):201-218.e17.
PMID: 39591969
Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide EV96 and its analogues...
7.
Salmon-Divon M, Meyuchas R, Shpilberg O, Okon E, Benhamida J, Yabe M, et al.
Leukemia
. 2024 Nov;
39(2):516-519.
PMID: 39516372
No abstract available.
8.
Ball B, Xiao W, Borthakur G, Truong Nguyen L, Valerio M, Venkatachalam A, et al.
Res Sq
. 2024 Nov;
PMID: 39483885
BTX-A51, a first-in-class oral small molecule inhibitor of casein kinase 1α (CK1α) and cyclin dependent kinase (CDK) 7 and 9, induces apoptosis of leukemic cells by activating p53 and inhibiting...
9.
Boussi L, Biswas J, Abdel-Wahab O, Stein E
Br J Haematol
. 2024 Oct;
205(6):2153-2162.
PMID: 39406457
In recent years, large-scale sequencing efforts have identified targetable driver mutations in haematopoietic stem cells. These efforts have led to the development and approval of nine novel agents for relapsed...
10.
Aakash F, Gisriel S, Zeidan A, Bennett J, Bejar R, Bewersdorf J, et al.
Mod Pathol
. 2024 Sep;
37(12):100615.
PMID: 39322118
Myelodysplastic neoplasms/syndromes (MDS) are a heterogeneous group of biologically distinct entities characterized by variable degrees of ineffective hematopoiesis. Recently, 2 classification systems (the 5th edition of the World Health Organization...