Olga Goldberger
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Explore the profile of Olga Goldberger including associated specialties, affiliations and a list of published articles.
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20
Citations
2435
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Recent Articles
1.
Singh C, Jin B, Shrestha N, Markhard A, Panda A, Calvo S, et al.
Cell Metab
. 2023 Dec;
36(1):144-158.e7.
PMID: 38101397
Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide association studies (GWASs), making GCKR one of the...
2.
Shi X, Reinstadler B, Shah H, To T, Byrne K, Summer L, et al.
Nat Commun
. 2022 May;
13(1):2483.
PMID: 35513392
The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors across mitochondrial membranes. The family is highly redundant and their transport activities coupled to metabolic state. Here,...
3.
Grange R, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper M, et al.
Mol Genet Metab
. 2021 Mar;
133(1):83-93.
PMID: 33752971
Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4 mouse model of Leigh syndrome, continuously breathing 11% O (hypoxia) prevents neurodegeneration and leads to...
4.
MacEwen M, Markhard A, Bozbeyoglu M, Bradford F, Goldberger O, Mootha V, et al.
Life Sci Alliance
. 2020 Aug;
3(10).
PMID: 32769116
The mitochondrial calcium uniporter (MCU) is a calcium-activated calcium channel critical for signaling and bioenergetics. MCU, the pore-forming subunit of the uniporter, contains two transmembrane domains and is found in...
5.
Goodman R, Markhard A, Shah H, Sharma R, Skinner O, Clish C, et al.
Nature
. 2020 May;
583(7814):122-126.
PMID: 32461692
The cellular NADH/NAD ratio is fundamental to biochemistry, but the extent to which it reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the in vivo...
6.
Jain I, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz G, Ast T, et al.
Cell Metab
. 2019 Aug;
30(4):824-832.e3.
PMID: 31402314
Leigh syndrome is a devastating mitochondrial disease for which there are no proven therapies. We previously showed that breathing chronic, continuous hypoxia can prevent and even reverse neurological disease in...
7.
Flicker D, Sancak Y, Mick E, Goldberger O, Mootha V
Cell Rep
. 2019 May;
27(5):1364-1375.e5.
PMID: 31042465
The mitochondrial calcium uniporter has been proposed to coordinate the organelle's energetics with calcium signaling. Uniporter current has previously been reported to be extremely high in brown adipose tissue (BAT),...
8.
Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, et al.
Am J Physiol Lung Cell Mol Physiol
. 2018 Dec;
316(2):L391-L399.
PMID: 30520688
Hypoxic pulmonary vasoconstriction (HPV) is a physiological vasomotor response that maintains systemic oxygenation by matching perfusion to ventilation during alveolar hypoxia. Although mitochondria appear to play an essential role in...
9.
Bick A, Wakimoto H, Kamer K, Sancak Y, Goldberger O, Axelsson A, et al.
Proc Natl Acad Sci U S A
. 2017 Oct;
114(43):E9096-E9104.
PMID: 29073106
Comparative analyses of transcriptional profiles from humans and mice with cardiovascular pathologies revealed consistently elevated expression of , a regulatory subunit of the mitochondrial calcium uniporter complex. To determine if...
10.
Ferrari M, Jain I, Goldberger O, Rezoagli E, Thoonen R, Cheng K, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(21):E4241-E4250.
PMID: 28483998
The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no...