Vamsi K Mootha
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Explore the profile of Vamsi K Mootha including associated specialties, affiliations and a list of published articles.
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55327
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Recent Articles
1.
Rogers R, Mootha V
Sci Transl Med
. 2025 Jan;
17(782):eadr4049.
PMID: 39841808
Oxygen is essential for human life, yet a growing body of preclinical research is demonstrating that chronic continuous hypoxia can be beneficial in models of mitochondrial disease, autoimmunity, ischemia, and...
2.
Wang H, Miranda M, Marutani E, Lichtenegger P, Wojtkiewicz G, Ichinose F, et al.
J Clin Invest
. 2024 Dec;
134(23).
PMID: 39621311
No abstract available.
3.
Foged M, Recazens E, Chollet S, Lisci M, Allen G, Zinshteyn B, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2414187121.
PMID: 39503847
Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a...
4.
LaMoia T, Hubbard B, Guerra M, Nasiri A, Sakuma I, Kahn M, et al.
Cell Metab
. 2024 Aug;
36(10):2329-2340.e4.
PMID: 39153480
To examine the roles of mitochondrial calcium Ca ([Ca]) and cytosolic Ca ([Ca]) in the regulation of hepatic mitochondrial fat oxidation, we studied a liver-specific mitochondrial calcium uniporter knockout (MCU...
5.
Tamaroff J, Nguyen S, Wilson N, Stefanovski D, Xiao R, Scattergood T, et al.
J Clin Endocrinol Metab
. 2024 Aug;
110(2):317-333.
PMID: 39109797
Introduction: Friedreich's ataxia (FRDA) is a multisystem disorder caused by frataxin deficiency. FRDA-related diabetes mellitus (DM) is common. Frataxin supports skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, a mediator of...
6.
Berra L, Medeiros K, Marrazzo F, Patel S, Imber D, Rezoagli E, et al.
Respir Care
. 2024 Jul;
69(11):1400-1408.
PMID: 39079724
Background: Beneficial effects of breathing at [Formula: see text] < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of...
7.
Gupta R, Kanai M, Durham T, Tsuo K, McCoy J, Kotrys A, et al.
Nature
. 2024 Jun;
630(8017):E10.
PMID: 38831054
No abstract available.
8.
Meisel J, Wiesenthal P, Mootha V, Ruvkun G
Curr Biol
. 2024 May;
34(12):2728-2738.e6.
PMID: 38810637
The mitochondrial proteome is comprised of approximately 1,100 proteins, all but 12 of which are encoded by the nuclear genome in C. elegans. The expression of nuclear-encoded mitochondrial proteins varies...
9.
Kotrys A, Durham T, Guo X, Vantaku V, Parangi S, Mootha V
Nature
. 2024 Apr;
629(8011):458-466.
PMID: 38658765
Heteroplasmy occurs when wild-type and mutant mitochondrial DNA (mtDNA) molecules co-exist in single cells. Heteroplasmy levels change dynamically in development, disease and ageing, but it is unclear whether these shifts...
10.
Lee J, Gohil V, Heidari P, Seidel J, Zulkifli M, Wei Y, et al.
Stroke
. 2024 Apr;
55(5):1370-1380.
PMID: 38572656
Background: Mild chemical inhibition of mitochondrial respiration can confer resilience against a subsequent stroke or myocardial infarction, also known as preconditioning. However, the lack of chemicals that can safely inhibit...