Hardik Shah
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Explore the profile of Hardik Shah including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Abraham P, Choudhuri G, Deshmukh S, Kak M, Tiwaskar M, Kochhar R, et al.
J Assoc Physicians India
. 2025 Mar;
73(3):e29-e36.
PMID: 40087940
Background: Approximately, 40% of gastroesophageal reflux disease (GERD) patients experience insufficient symptom relief from proton-pump inhibitors (PPI), resulting in PPI-refractory GERD (rGERD). Objective: To review the existing literature and develop...
2.
Nengroo M, Klein A, Carr H, Vidal-Cruchez O, Sahu U, McGrail D, et al.
bioRxiv
. 2025 Mar;
PMID: 40060604
The de novo purine synthesis pathway is fundamental for nucleic acid production and cellular energetics, yet the role of mitochondrial metabolism in modulating this process remains underexplored. In many cancers,...
3.
Tiwari V, Jin B, Sun O, Lopez Gonzalez E, Chen M, Wu X, et al.
bioRxiv
. 2025 Jan;
PMID: 39763913
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD do...
4.
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
Liu R, Ren X, Park Y, Feng H, Sheng X, Song X, et al.
Cell Metab
. 2024 Dec;
37(2):377-394.e9.
PMID: 39642882
Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate...
5.
Hamanaka R, Shin K, Atalay M, Cetin-Atalay R, Shah H, Szafran J, et al.
bioRxiv
. 2024 Nov;
PMID: 39554075
Arginine is a conditionally essential amino acid with known roles in protein production, nitric oxide synthesis, biosynthesis of proline and polyamines, and regulation of intracellular signaling pathways. Arginine biosynthesis and...
6.
Yang H, Zingaro V, Lincoff J, Tom H, Oikawa S, Oses-Prieto J, et al.
Nature
. 2024 Aug;
633(8028):189-197.
PMID: 39143206
Fasting is associated with a range of health benefits. How fasting signals elicit changes in the proteome to establish metabolic programmes remains poorly understood. Here we show that hepatocytes selectively...
7.
Tamaroff J, Nguyen S, Wilson N, Stefanovski D, Xiao R, Scattergood T, et al.
J Clin Endocrinol Metab
. 2024 Aug;
110(2):317-333.
PMID: 39109797
Introduction: Friedreich's ataxia (FRDA) is a multisystem disorder caused by frataxin deficiency. FRDA-related diabetes mellitus (DM) is common. Frataxin supports skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, a mediator of...
8.
Berra L, Medeiros K, Marrazzo F, Patel S, Imber D, Rezoagli E, et al.
Respir Care
. 2024 Jul;
69(11):1400-1408.
PMID: 39079724
Background: Beneficial effects of breathing at [Formula: see text] < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of...
9.
Gewurz B, Guo R, Lim M, Shah H, Paulo J, Zhang Y, et al.
Res Sq
. 2024 Jun;
PMID: 38854072
B-lymphocytes play major adaptive immune roles, producing antibody and driving T-cell responses. However, how immunometabolism networks support B-cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood....
10.
Song X, Tiek D, Miki S, Huang T, Lu M, Goenka A, et al.
J Clin Invest
. 2024 Apr;
134(11).
PMID: 38662454
Widespread alterations in RNA alternative splicing (AS) have been identified in adult gliomas. However, their regulatory mechanism, biological significance, and therapeutic potential remain largely elusive. Here, using a computational approach...