Andrew L Markhard
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Explore the profile of Andrew L Markhard including associated specialties, affiliations and a list of published articles.
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14
Citations
3433
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Recent Articles
1.
Wei W, Lyu X, Markhard A, Fu S, Mardjuki R, Cavanagh P, et al.
Nature
. 2024 Aug;
633(8028):182-188.
PMID: 39112712
Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans. In endogenous taurine metabolism, dedicated enzymes are involved in the biosynthesis of taurine from...
2.
Wei W, Lyu X, Markhard A, Fu S, Mardjuki R, Cavanagh P, et al.
bioRxiv
. 2024 Apr;
PMID: 38562797
Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine...
3.
Singh C, Jin B, Shrestha N, Markhard A, Panda A, Calvo S, et al.
Cell Metab
. 2023 Dec;
36(1):144-158.e7.
PMID: 38101397
Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide association studies (GWASs), making GCKR one of the...
4.
Rogers R, Wang H, Durham T, Stefely J, Owiti N, Markhard A, et al.
PLoS Biol
. 2023 May;
21(5):e3002117.
PMID: 37220109
There is widespread interest in identifying interventions that extend healthy lifespan. Chronic continuous hypoxia delays the onset of replicative senescence in cultured cells and extends lifespan in yeast, nematodes, and...
5.
Ganetzky R, Markhard A, Yee I, Clever S, Cahill A, Shah H, et al.
N Engl J Med
. 2022 Oct;
387(15):1395-1403.
PMID: 36239646
We describe the case of identical twin boys who presented with low body weight despite excessive caloric intake. An evaluation of their fibroblasts showed elevated oxygen consumption and decreased mitochondrial...
6.
Markhard A, McCoy J, To T, Mootha V
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2207955119.
PMID: 36215519
Oxygen plays a key role in supporting life on our planet. It is particularly important in higher eukaryotes where it boosts bioenergetics as a thermodynamically favorable terminal electron acceptor and...
7.
MacEwen M, Markhard A, Bozbeyoglu M, Bradford F, Goldberger O, Mootha V, et al.
Life Sci Alliance
. 2020 Aug;
3(10).
PMID: 32769116
The mitochondrial calcium uniporter (MCU) is a calcium-activated calcium channel critical for signaling and bioenergetics. MCU, the pore-forming subunit of the uniporter, contains two transmembrane domains and is found in...
8.
Goodman R, Markhard A, Shah H, Sharma R, Skinner O, Clish C, et al.
Nature
. 2020 May;
583(7814):122-126.
PMID: 32461692
The cellular NADH/NAD ratio is fundamental to biochemistry, but the extent to which it reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the in vivo...
9.
Jain I, Calvo S, Markhard A, Skinner O, To T, Ast T, et al.
Cell
. 2020 Apr;
181(3):716-727.e11.
PMID: 32259488
Human cells are able to sense and adapt to variations in oxygen levels. Historically, much research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive oxygen species...
10.
Markowitz T, Suarez D, Blitzblau H, Patel N, Markhard A, MacQueen A, et al.
PLoS Genet
. 2017 Jul;
13(7):e1006928.
PMID: 28746375
Meiotic chromosomes assemble characteristic "axial element" structures that are essential for fertility and provide the chromosomal context for meiotic recombination, synapsis and checkpoint signaling. Whether these meiotic processes are equally...