Olga Gealekman
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Explore the profile of Olga Gealekman including associated specialties, affiliations and a list of published articles.
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12
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817
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Recent Articles
1.
Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, et al.
J Biol Chem
. 2014 Apr;
289(26):18327-38.
PMID: 24778188
Adipose tissue expansion requires growth and proliferation of adipocytes and the concomitant expansion of their stromovascular network. We have used an ex vivo angiogenesis assay to study the mechanisms involved...
2.
Rojas-Rodriguez R, Gealekman O, Kruse M, Rosenthal B, Rao K, Min S, et al.
Methods Enzymol
. 2014 Feb;
537:75-91.
PMID: 24480342
Changes in adipose tissue mass must be accompanied by parallel changes in microcirculation. Investigating the mechanisms that regulate adipose tissue angiogenesis could lead to better understanding of adipose tissue function...
3.
Corvera S, Gealekman O
Biochim Biophys Acta
. 2013 Jun;
1842(3):463-72.
PMID: 23770388
The growth and function of tissues are critically dependent on their vascularization. Adipose tissue is capable of expanding many-fold during adulthood, therefore requiring the formation of new vasculature to supply...
4.
Tran K, Gealekman O, Frontini A, Zingaretti M, Morroni M, Giordano A, et al.
Cell Metab
. 2012 Feb;
15(2):222-9.
PMID: 22326223
Adipose tissue expansion involves the enlargement of existing adipocytes, the formation of new cells from committed preadipocytes, and the coordinated development of the tissue vascular network. Here we find that...
5.
Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M, Gurav K, et al.
Circulation
. 2011 Jan;
123(2):186-94.
PMID: 21200001
Background: Adipose tissue expands in response to excess caloric intake, but individuals prone to deposit visceral instead of subcutaneous adipose tissue have higher risk of metabolic disease. The role of...
6.
Gealekman O, Burkart A, Chouinard M, Nicoloro S, Straubhaar J, Corvera S
Am J Physiol Endocrinol Metab
. 2008 Aug;
295(5):E1056-64.
PMID: 18728224
PPARgamma activators such as rosiglitazone (RSG) stimulate adipocyte differentiation and increase subcutaneous adipose tissue mass. However, in addition to preadipocyte differentiation, adipose tissue expansion requires neovascularization to support increased adipocyte...
7.
Patschan S, Chen J, Gealekman O, Krupincza K, Wang M, Shu L, et al.
Am J Physiol Renal Physiol
. 2007 Oct;
294(1):F100-9.
PMID: 17928415
Endothelial cells subjected to glycated collagen I develop premature senescence within 3-5 days, as revealed by increased senescence-associated beta-galactosidase activity, decreased proliferation, and an increase in cell size. Here, we...
8.
Gealekman O, Brodsky S, Zhang F, Chander P, Friedli C, Nasjletti A, et al.
Kidney Int
. 2004 Dec;
66(6):2337-47.
PMID: 15569324
Background: Progression of nephropathy in metabolic syndrome is associated with microvasculopathy and vascular dropout. Methods: Eight- and 22-week-old Zucker diabetic fat (ZDF) and Zucker lean (ZL) rats were studied to...
9.
Chander P, Gealekman O, Brodsky S, Elitok S, Tojo A, Crabtree M, et al.
J Am Soc Nephrol
. 2004 Sep;
15(9):2391-403.
PMID: 15339988
Zucker diabetic fat (ZDF) rats with the metabolic syndrome and hyperlipidemia develop focal and segmental sclerosis. The role of oxidative and nitrosative stress in the nephropathy in ZDF was studied....
10.
Arriero M, Brodsky S, Gealekman O, Lucas P, Goligorsky M
Am J Physiol Renal Physiol
. 2004 Jun;
287(4):F621-7.
PMID: 15198930
We previously demonstrated that endothelial cells are severely damaged during renal ischemia-reperfusion and that transplantation of adult human endothelial cells into athymic nude rats subjected to renal ischemia resulted in...