Nikolaus Fortelny
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Explore the profile of Nikolaus Fortelny including associated specialties, affiliations and a list of published articles.
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32
Citations
1270
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Recent Articles
1.
Karjalainen A, Witalisz-Siepracka A, Prchal-Murphy M, Martin D, Sternberg F, Krunic M, et al.
Cell Mol Life Sci
. 2025 Mar;
82(1):98.
PMID: 40025196
Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin...
2.
Elmer D, Stockmaier G, Grund-Groschke S, Strobl V, Dang H, Wiederstein M, et al.
Cell Commun Signal
. 2025 Feb;
23(1):91.
PMID: 39962447
Background: Pharmacological targeting of Hedgehog (HH)/GLI has proven effective for certain blood, brain and skin cancers including basal cell carcinoma (BCC). However, limited response rates and the development of drug...
3.
Neuper T, Frauenlob T, Dang H, Krenn P, Posselt G, Regl C, et al.
Gut Microbes
. 2024 Sep;
16(1):2402543.
PMID: 39288239
Sophisticated immune evasion strategies enable to colonize the gastric mucosa of approximately half of the world's population. Persistent infection and the resulting chronic inflammation are a major cause of gastric...
4.
Fortelny N, Farlik M, Fife V, Gorki A, Lassnig C, Maurer B, et al.
Nat Immunol
. 2024 Apr;
25(5):847-859.
PMID: 38658806
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is...
5.
Esser-Skala W, Fortelny N
NPJ Syst Biol Appl
. 2023 Oct;
9(1):50.
PMID: 37816807
Deep neural networks display impressive performance but suffer from limited interpretability. Biology-inspired deep learning, where the architecture of the computational graph is based on biological knowledge, enables unique interpretability where...
6.
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
Lara-Astiaso D, Goni-Salaverri A, Mendieta-Esteban J, Narayan N, Del Valle C, Gross T, et al.
Nat Genet
. 2023 Aug;
55(9):1542-1554.
PMID: 37580596
Cellular differentiation requires extensive alterations in chromatin structure and function, which is elicited by the coordinated action of chromatin and transcription factors. By contrast with transcription factors, the roles of...
7.
Kiss M, Papac-Milicevic N, Porsch F, Tsiantoulas D, Hendrikx T, Takaoka M, et al.
Immunity
. 2023 Jul;
56(8):1809-1824.e10.
PMID: 37499656
Complement factor H (CFH) negatively regulates consumption of complement component 3 (C3), thereby restricting complement activation. Genetic variants in CFH predispose to chronic inflammatory disease. Here, we examined the impact...
8.
Fetahu I, Esser-Skala W, Dnyansagar R, Sindelar S, Rifatbegovic F, Bileck A, et al.
Nat Commun
. 2023 Jun;
14(1):3620.
PMID: 37365178
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic...
9.
Klughammer J, Romanovskaia D, Nemc A, Posautz A, Seid C, Schuster L, et al.
Nat Commun
. 2023 Jan;
14(1):232.
PMID: 36646694
Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been implicated in various regulatory mechanisms across the animal kingdom and particularly in vertebrates. We mapped DNA...
10.
Boccuni L, Podgorschek E, Schmiedeberg M, Platanitis E, Traxler P, Fischer P, et al.
Sci Signal
. 2022 Dec;
15(764):eabq5389.
PMID: 36512641
Promoters of antimicrobial genes function as logic boards, integrating signals of innate immune responses. One such set of genes is stimulated by interferon (IFN) signaling, and the expression of these...