Matthias Farlik
Overview
Explore the profile of Matthias Farlik including associated specialties, affiliations and a list of published articles.
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64
Citations
3438
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Recent Articles
1.
Jorda A, Pracher L, Eberl S, Nussbaumer-Proll A, Sarhan M, Weber M, et al.
Med Microbiol Immunol
. 2025 Mar;
214(1):14.
PMID: 40047923
Whether the magnitude of individual cytokine, cellular, and clinical responses to the intravenous lipopolysaccharide (LPS) challenge is constant in individuals over extended time periods is unknown. Nine healthy volunteers received...
2.
Karjalainen A, Witalisz-Siepracka A, Prchal-Murphy M, Martin D, Sternberg F, Krunic M, et al.
Cell Mol Life Sci
. 2025 Mar;
82(1):98.
PMID: 40025196
Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin...
3.
Ressler J, Plaschka M, Silmbrod R, Bachmayr V, Shaw L, Silly T, et al.
Nat Cancer
. 2025 Jan;
6(1):51-66.
PMID: 39820126
We present a single-arm, phase II, neoadjuvant trial with the oncolytic virus talimogene laherparepvec (T-VEC) in 18 patients with difficult-to-resect cutaneous basal cell carcinomas. The primary end point, defined as...
4.
Ransmayr B, Bal S, Thian M, Svaton M, van de Wetering C, Hafemeister C, et al.
Sci Immunol
. 2024 Nov;
9(101):eadq8796.
PMID: 39576873
Secondary lymphoid organs (SLOs) provide the confined microenvironment required for stromal cells to interact with immune cells to initiate adaptive immune responses resulting in B cell differentiation. Here, we studied...
5.
Strobl K, Klufa J, Jin R, Artner-Gent L, Krauss D, Novoszel P, et al.
EMBO Mol Med
. 2024 Nov;
16(12):3142-3168.
PMID: 39521937
The hair follicle stem cell niche is an immune-privileged microenvironment, characterized by reduced antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrated the protective role...
6.
Kabiljo J, Theophil A, Homola J, Renner A, Sturzenbecher N, Ammon D, et al.
J Immunother Cancer
. 2024 Nov;
12(11).
PMID: 39500527
Background: Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the absence of...
7.
Stary V, Pandey R, List J, Kleissl L, Deckert F, Kabiljo J, et al.
Nat Commun
. 2024 Aug;
15(1):6949.
PMID: 39138181
Although γδ T cells are known to participate in immune dysregulation in solid tumors, their relevance to human microsatellite-stable (MSS) colorectal cancer (CRC) is still undefined. Here, using integrated gene...
8.
Jorda A, Eberl S, Nussbaumer-Proll A, Sarhan M, Weber M, Tegrovsky L, et al.
J Inflamm Res
. 2024 Jul;
17:4781-4790.
PMID: 39051050
Introduction: Lipopolysaccharide (LPS) stimulation of human whole blood ex vivo has been widely used to investigate human innate immune responses. However, there are uncertainties regarding the reproducibility and reliability of...
9.
Saldana-Guerrero I, Montano-Gutierrez L, Boswell K, Hafemeister C, Poon E, Shaw L, et al.
Nat Commun
. 2024 May;
15(1):3745.
PMID: 38702304
Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack...
10.
Mayer I, Doma E, Klampfl T, Prchal-Murphy M, Kollmann S, Schirripa A, et al.
Blood
. 2024 Apr;
144(2):156-170.
PMID: 38684032
Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to replenish the hematopoietic system. The cell-cycle kinase cyclin-dependent kinase 6 (CDK6) regulates transcription, whereby it has both...