Nicolas Wieder
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Explore the profile of Nicolas Wieder including associated specialties, affiliations and a list of published articles.
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15
Citations
274
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Recent Articles
1.
Becker A, Wieder N, Zonnur S, Zimpfer A, Krause M, Schneider B, et al.
Discov Oncol
. 2024 Dec;
15(1):745.
PMID: 39630300
We retrospectively analyzed 129 treatment-naïve head and neck squamous cell carcinomas (HNSCCs) for the expression of programmed death ligand 1 (PD-L1), CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6), tumor-infiltrating leukocytes (TILs),...
2.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
Cell Metab
. 2023 Apr;
35(5):887-905.e11.
PMID: 37075753
Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated diseases. However, there are no scalable approaches to comprehensively assess the diverse FFAs circulating in human...
3.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865221
Highlights: FALCON (Fatty Acid Library for Comprehensive ONtologies) enables multimodal profiling of 61 free fatty acids (FFAs) to reveal 5 FFA clusters with distinct biological effectsFALCON is applicable to many...
4.
Sidhom E, Kim C, Kost-Alimova M, Ting M, Keller K, Avila-Pacheco J, et al.
J Clin Invest
. 2021 Jan;
131(5).
PMID: 33444290
Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss of podocytes, essential cells of the kidney filter. Curiously, neighboring tubular epithelial cells are spared...
5.
Wieder N, H A Fink R, von Wegner F
Adv Exp Med Biol
. 2019 Oct;
1131:771-797.
PMID: 31646534
In this article, we present an overview of simulation strategies in the context of subcellular domains where calcium-dependent signaling plays an important role. The presentation follows the spatial and temporal...
6.
Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom E, et al.
Cell
. 2019 Jul;
178(3):521-535.e23.
PMID: 31348885
Intracellular accumulation of misfolded proteins causes toxic proteinopathies, diseases without targeted therapies. Mucin 1 kidney disease (MKD) results from a frameshift mutation in the MUC1 gene (MUC1-fs). Here, we show...
7.
Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, et al.
Cell Chem Biol
. 2017 Dec;
25(2):175-184.e4.
PMID: 29249695
Progressive kidney diseases affect approximately 500 million people worldwide. Podocytes are terminally differentiated cells of the kidney filter, the loss of which leads to disease progression and kidney failure. To...
8.
Zhou Y, Castonguay P, Sidhom E, Clark A, Dvela-Levitt M, Kim S, et al.
Science
. 2017 Dec;
358(6368):1332-1336.
PMID: 29217578
Progressive kidney diseases are often associated with scarring of the kidney's filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical...
9.
Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygun O, Udeshi N, et al.
J Biol Chem
. 2017 Sep;
292(46):18878-18885.
PMID: 28912266
The up-regulation of chaperones such as the 78-kDa glucose-regulated protein (GRP78, also referred to as BiP or HSPA5) is part of the adaptive cellular response to endoplasmic reticulum (ER) stress....
10.
Wieder N, Greka A
Pediatr Nephrol
. 2015 Oct;
31(7):1047-54.
PMID: 26490951
With more than 6,000 new pediatric patients with treatment-resistant nephrotic syndrome in the US each year alone, the unmet need for novel, podocyte-specific therapies is substantial. Recently, the established therapeutic...