Nicolas Demaurex
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Explore the profile of Nicolas Demaurex including associated specialties, affiliations and a list of published articles.
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105
Citations
4033
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Recent Articles
11.
Kim J, Carreras-Sureda A, Didier M, Henry C, Frieden M, Demaurex N
Cell Calcium
. 2022 Jul;
105:102615.
PMID: 35792400
Tubular aggregate myopathy (TAM) is a progressive skeletal muscle disease associated with gain-of-function mutations in the ER Ca sensor STIM1 that mediates store-operated Ca entry (SOCE) across the Ca-release-activated (CRAC)...
12.
Enforced tethering elongates the cortical endoplasmic reticulum and limits store-operated Ca2+ entry
Henry C, Carreras-Sureda A, Demaurex N
J Cell Sci
. 2022 Feb;
135(6).
PMID: 35191477
Recruitment of STIM proteins to cortical endoplasmic reticulum (cER) domains forming membrane contact sites (MCSs) mediate the store-operated Ca2+ entry (SOCE) pathway essential for human immunity. The cER is dynamically...
13.
Wang W, Demaurex N
J Biol Chem
. 2022 Jan;
298(3):101607.
PMID: 35065962
The stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum (ER) Ca sensor that regulates the activity of Orai plasma membrane Ca channels to mediate the store-operated Ca entry pathway...
14.
Carreras-Sureda A, Abrami L, Ji-Hee K, Wang W, Henry C, Frieden M, et al.
Elife
. 2021 Dec;
10.
PMID: 34913437
Efficient immune responses require Ca fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we...
15.
Pihan P, Lisbona F, Borgonovo J, Edwards-Jorquera S, Nunes-Hasler P, Castillo K, et al.
Sci Adv
. 2021 Nov;
7(46):eabe5469.
PMID: 34767445
Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress 1) [also known as TMBIM1...
16.
Pihan P, Nunes-Hasler P, Demaurex N, Hetz C
Methods Cell Biol
. 2021 Jul;
165:199-208.
PMID: 34311868
The lysosome is the main catabolic organelle in the cell, also serving as a signaling platform. Lysosomes maintain a low intraluminal pH where dozens of hydrolytic enzymes degrade a wide...
17.
Wang W, Demaurex N
Prog Mol Subcell Biol
. 2021 May;
59:51-97.
PMID: 34050862
The endoplasmic reticulum (ER) Ca sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes...
18.
Nunes-Hasler P, Kaba M, Demaurex N
Adv Exp Med Biol
. 2020 May;
1246:103-128.
PMID: 32399828
Calcium (Ca) is a ubiquitous second messenger involved in the regulation of numerous cellular functions including vesicular trafficking, cytoskeletal rearrangements and gene transcription. Both global as well as localized Ca...
19.
Saul S, Castelbou C, Fickentscher C, Demaurex N
J Leukoc Biol
. 2019 Jun;
106(5):1101-1115.
PMID: 31216372
Neutrophils play a central role in immunity and inflammation via their intrinsic ability to migrate into inflamed tissue, to phagocytose pathogens, and to kill bacterial and fungi by releasing large...
20.
Rosselin M, Nunes-Hasler P, Demaurex N
Contact (Thousand Oaks)
. 2018 Nov;
1(1):1-14.
PMID: 30406212
Mitochondria undergo spontaneous transient elevations in matrix pH associated with drops in mitochondrial membrane potential. These require a functional respiratory chain and the profusion protein optic atrophy 1, but their...