Proteins Interacting with STIM1 and Store-Operated Ca Entry

Overview

Journal Prog Mol Subcell Biol

Specialties Biochemistry
Molecular Biology

Date 2021 May 29

PMID 34050862

Citations 1

Authors

Wen-An Wang

Nicolas Demaurex

Affiliations

Soon will be listed here.

Abstract

The endoplasmic reticulum (ER) Ca sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca entry (SOCE).

Citing Articles

Antioxidants restore store-operated Ca entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein.

Sakai-Takemura F, Saito F, Nogami K, Maruyama Y, Elhussieny A, Matsumura K FASEB Bioadv. 2023; 5(11):453-469.

PMID: 37936920 PMC: 10626159. DOI: 10.1096/fba.2023-00069.

References

Alansary D, Bogeski I, Niemeyer B . Facilitation of Orai3 targeting and store-operated function by Orai1. Biochim Biophys Acta. 2015; 1853(7):1541-50. DOI: 10.1016/j.bbamcr.2015.03.007. View

Albarran L, Lopez J, Ben Amor N, Martin-Cano F, Berna-Erro A, Smani T . Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry. Sci Rep. 2016; 6:24452. PMC: 4828706. DOI: 10.1038/srep24452. View

Albarran L, Lopez J, Woodard G, Salido G, Rosado J . Store-operated Ca2+ Entry-associated Regulatory factor (SARAF) Plays an Important Role in the Regulation of Arachidonate-regulated Ca2+ (ARC) Channels. J Biol Chem. 2016; 291(13):6982-8. PMC: 4807282. DOI: 10.1074/jbc.M115.704940. View

Albarran L, Lopez J, Jardin I, Sanchez-Collado J, Berna-Erro A, Smani T . EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction. Cell Physiol Biochem. 2018; 51(3):1164-1178. DOI: 10.1159/000495494. View

Alicia S, Angelica Z, Carlos S, Alfonso S, Vaca L . STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts. Cell Calcium. 2008; 44(5):479-91. DOI: 10.1016/j.ceca.2008.03.001. View

Almirza W, Peters P, van Zoelen E, Theuvenet A . Role of Trpc channels, Stim1 and Orai1 in PGF(2α)-induced calcium signaling in NRK fibroblasts. Cell Calcium. 2011; 51(1):12-21. DOI: 10.1016/j.ceca.2011.10.001. View

Asanov A, Sherry R, Sampieri A, Vaca L . A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell Calcium. 2013; 54(3):246-56. DOI: 10.1016/j.ceca.2013.06.008. View

Baryshnikov S, Pulina M, Zulian A, Linde C, Golovina V . Orai1, a critical component of store-operated Ca2+ entry, is functionally associated with Na+/Ca2+ exchanger and plasma membrane Ca2+ pump in proliferating human arterial myocytes. Am J Physiol Cell Physiol. 2009; 297(5):C1103-12. PMC: 2777402. DOI: 10.1152/ajpcell.00283.2009. View

Bauer M, OConnell D, Cahill D, Linse S . Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry. Biochemistry. 2008; 47(23):6089-91. DOI: 10.1021/bi800496a. View

10.

Beliveau E, Lessard V, Guillemette G . STIM1 positively regulates the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor in bovine aortic endothelial cells. PLoS One. 2014; 9(12):e114718. PMC: 4266619. DOI: 10.1371/journal.pone.0114718. View

11.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P . Molecular determinants within N terminus of Orai3 protein that control channel activation and gating. J Biol Chem. 2011; 286(36):31565-75. PMC: 3173129. DOI: 10.1074/jbc.M111.227546. View

12.

Bhardwaj R, Muller H, Nickel W, Seedorf M . Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids. Biosci Rep. 2013; 33(5). PMC: 3814058. DOI: 10.1042/BSR20130089. View

13.

Bhardwaj R, Augustynek B, Ercan-Herbst E, Kandasamy P, Seedorf M, Peinelt C . Ca/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca-Dependent Inactivation of the Orai1 Channel. Cell Physiol Biochem. 2020; 54(2):252-270. DOI: 10.33594/000000218. View

14.

Boulay G, Brown D, Qin N, Jiang M, Dietrich A, Zhu M . Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A. 1999; 96(26):14955-60. PMC: 24754. DOI: 10.1073/pnas.96.26.14955. View

15.

Butorac C, Muik M, Derler I, Stadlbauer M, Lunz V, Krizova A . A novel STIM1-Orai1 gating interface essential for CRAC channel activation. Cell Calcium. 2019; 79:57-67. DOI: 10.1016/j.ceca.2019.02.009. View

16.

Chang C, Chen Y, Quintanilla C, Hsieh T, Liou J . EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca entry. J Cell Biol. 2018; 217(6):2047-2058. PMC: 5987725. DOI: 10.1083/jcb.201711151. View

17.

Cully T, Edwards J, Friedrich O, Stephenson D, Murphy R, Launikonis B . Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca(2+) signaling in dystrophic mdx mouse muscle. Am J Physiol Cell Physiol. 2012; 303(5):C567-76. DOI: 10.1152/ajpcell.00144.2012. View

18.

Dai F, Zhang Y, Wang Q, Li D, Yang Y, Ma S . Overexpression of SARAF Ameliorates Pressure Overload-Induced Cardiac Hypertrophy Through Suppressing STIM1-Orai1 in Mice. Cell Physiol Biochem. 2018; 47(2):817-826. DOI: 10.1159/000490036. View

19.

Decker C, Yang Z, Rimer R, Park-Min K, Macaubas C, Mellins E . Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. Proc Natl Acad Sci U S A. 2015; 112(51):15654-9. PMC: 4697402. DOI: 10.1073/pnas.1511285112. View

20.

DeHaven W, Smyth J, Boyles R, Putney Jr J . Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. J Biol Chem. 2007; 282(24):17548-56. DOI: 10.1074/jbc.M611374200. View