Damon Poburko
Overview
Explore the profile of Damon Poburko including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
813
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Recent Articles
1.
Rothwell S, Ng I, Shalchy-Tabrizi S, Kalinowski P, Taha O, Paris I, et al.
Front Physiol
. 2025 Mar;
15:1488248.
PMID: 40034369
Introduction: Mitochondrial dysfunction promotes vascular aging and disease through diverse mechanisms beyond metabolic supply, including calcium and radical signaling and inflammation. Mitochondrial DNA (mtDNA) replication by the POLG-encoded mitochondrial DNA...
2.
Simpson K, Faizi S, Venkateshappa R, Yip M, Johal R, Poburko D, et al.
J Vis Exp
. 2022 Oct;
(187).
PMID: 36190280
Clustered regularly interspaced short palindromic repeats (CRISPR) in animal models enable precise genetic manipulation for the study of physiological phenomena. Zebrafish have been used as an effective genetic model to...
3.
Li B, Kalinowski P, Kim B, Pauls A, Poburko D
Pharmacol Ther
. 2021 Sep;
232:107995.
PMID: 34592204
The past thirty years have seen a surge in interest in pathophysiological roles of mitochondria, and the accurate quantification of mitochondrial DNA copy number (mCN) in cells and tissue samples...
4.
Ghovanloo M, Choudhury K, Bandaru T, Fouda M, Rayani K, Rusinova R, et al.
J Gen Physiol
. 2021 Apr;
153(5).
PMID: 33836525
Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions, including muscle spasms. Among its putative targets are voltage-gated...
5.
Kim B, Molina R, Jensen G, Poburko D
Cell Calcium
. 2021 Mar;
96:102369.
PMID: 33677175
Vascular smooth muscle cells are unusual in that differentiated, contractile cells possess the capacity to "de-differentiate" into a synthetic phenotype that is characterized by being replicative, secretory, and migratory. One...
6.
Pauls A, Sandhu V, Young D, Nevay D, Yeung D, Sirrs S, et al.
Mitochondrion
. 2020 Jun;
53:194-202.
PMID: 32502631
Animal studies suggest that decreased vascular mitochondrial DNA copy number can promote hypertension. We conducted a chart review of blood pressure and hemodynamics in patients with either mitochondrial encephalopathy, lactic...
7.
Angus M, Peters C, Poburko D, Brimble E, Spelbrink E, Ruben P
J Neurophysiol
. 2019 Sep;
122(5):1975-1980.
PMID: 31533007
Dravet syndrome is a severe form of childhood epilepsy characterized by frequent temperature-sensitive seizures and delays in cognitive development. In the majority (80%) of cases, Dravet syndrome is caused by...
8.
Mojard Kalkhoran S, Chow S, Walia J, Gershome C, Saraev N, Kim B, et al.
Am J Physiol Heart Circ Physiol
. 2018 Oct;
316(1):H89-H105.
PMID: 30311774
ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP...
9.
Li B, Kaushik S, Kalinowski P, Kim B, Gershome C, Ching J, et al.
Sci Rep
. 2018 Aug;
8(1):11392.
PMID: 30061621
Absolute quantification of mitochondrial DNA copy number (mCN) provides important insights in many fields of research including cancer, cardiovascular and reproductive health. Droplet digital PCR (ddPCR) natively reports absolute copy...
10.
Lehman A, Thouta S, Mancini G, Naidu S, van Slegtenhorst M, McWalter K, et al.
Am J Hum Genet
. 2017 Jul;
101(1):65-74.
PMID: 28669405
KCNQ5 is a highly conserved gene encoding an important channel for neuronal function; it is widely expressed in the brain and generates M-type current. Exome sequencing identified de novo heterozygous...