Nicholas M Riley
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Explore the profile of Nicholas M Riley including associated specialties, affiliations and a list of published articles.
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70
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2125
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Recent Articles
1.
Sutherland E, Veth T, Riley N
J Am Soc Mass Spectrom
. 2025 Jan;
36(3):457-462.
PMID: 39887243
Deamidation of asparagine and glutamine residues occurs spontaneously, is influenced by pH, temperature, and incubation time, and can be accelerated by adjacent amino acid residues. Incubation conditions used for proteolytic...
2.
Hvorecny K, Interlandi G, Veth T, Aprikian P, Manchenko A, Tchesnokova V, et al.
bioRxiv
. 2024 Dec;
PMID: 39713463
A critical step in infections is the attachment of many microorganisms to host cells using lectins that bind surface glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH,...
3.
Sutherland E, Veth T, Barshop W, Russell J, Kothlow K, Canterbury J, et al.
J Proteome Res
. 2024 Nov;
23(12):5606-5614.
PMID: 39531532
Tandem mass spectrometry (MS/MS) is the gold standard for intact glycopeptide identification, enabling peptide sequence elucidation and site-specific localization of glycan compositions. Beam-type collisional activation is generally sufficient for glycopeptides,...
4.
Wen R, Stark J, Marti G, Fan Z, Lyu A, Marques F, et al.
J Clin Invest
. 2024 Oct;
134(24).
PMID: 39436703
Prostate cancer is the second leading cause of male cancer death in the U.S. Current immune checkpoint inhibitor-based immunotherapies have improved survival for many malignancies; however, they have failed to...
5.
Ducoli L, Zarnegar B, Porter D, Meyers R, Miao W, Riley N, et al.
bioRxiv
. 2024 Oct;
PMID: 39386644
RNA binding proteins ( RBPs ) control varied processes, including RNA splicing, stability, transport, and translation . Dysfunctional RNA-RBP interactions contribute to the pathogenesis of human disease , however, characterizing...
6.
Jiang Y, Rex D, Schuster D, Neely B, Rosano G, Volkmar N, et al.
ACS Meas Sci Au
. 2024 Aug;
4(4):338-417.
PMID: 39193565
Proteomics is the large scale study of protein structure and function from biological systems through protein identification and quantification. "Shotgun proteomics" or "bottom-up proteomics" is the prevailing strategy, in which...
7.
Hogan R, Pepi L, Riley N, Chalkley R
bioRxiv
. 2024 Aug;
PMID: 39091841
Glycoproteomics is a rapidly developing field, and data analysis has been stimulated by several technological innovations. As a result, there are many software tools from which to choose; and each...
8.
Peters-Clarke T, Coon J, Riley N
Anal Chem
. 2024 May;
96(20):7976-8010.
PMID: 38738990
No abstract available.
9.
Goyette M, Stevens L, DePinho C, Seehawer M, Nishida J, Li Z, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(20):e2322688121.
PMID: 38709925
Brain metastatic breast cancer is particularly lethal largely due to therapeutic resistance. Almost half of the patients with metastatic HER2-positive breast cancer develop brain metastases, representing a major clinical challenge....
10.
Stewart N, Daly J, Drummond-Guy O, Krishnamoorthy V, Stark J, Riley N, et al.
J Biol Chem
. 2023 Dec;
300(2):105579.
PMID: 38141764
Siglec-7 (sialic acid-binding immunoglobulin-like lectin 7) is a glycan-binding immune receptor that is emerging as a significant target of interest for cancer immunotherapy. The physiological ligands that bind Siglec-7, however,...