Michael S Westphall
Overview
Explore the profile of Michael S Westphall including associated specialties, affiliations and a list of published articles.
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107
Citations
3968
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Recent Articles
1.
Lancaster N, Sinitcyn P, Forny P, Peters-Clarke T, Fecher C, Smith A, et al.
Nat Commun
. 2024 Aug;
15(1):7016.
PMID: 39147754
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe...
2.
Peters-Clarke T, Liang Y, Mertz K, Lee K, Westphall M, Hinkle J, et al.
J Proteome Res
. 2024 May;
PMID: 38713017
Single-cell proteomics is a powerful approach to precisely profile protein landscapes within individual cells toward a comprehensive understanding of proteomic functions and tissue and cellular states. The inherent challenges associated...
3.
Peters-Clarke T, Quan Q, Anderson B, McGee W, Lohr E, Hebert A, et al.
Mol Cell Proteomics
. 2024 Feb;
23(4):100742.
PMID: 38401707
Therapeutic RNAs are routinely modified during their synthesis to ensure proper drug uptake, stability, and efficacy. Phosphorothioate (PS) RNA, molecules in which one or more backbone phosphates are modified with...
4.
Lancaster N, Sinitcyn P, Forny P, Peters-Clarke T, Fecher C, Smith A, et al.
bioRxiv
. 2023 Dec;
PMID: 38045259
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe...
5.
Westphall M, Lee K, Hemme C, Salome A, Mertz K, Grant T, et al.
Anal Chem
. 2023 Sep;
95(40):15094-15101.
PMID: 37732836
We describe an apparatus for the cryogenic landing of particles from the ion beam of a mass spectrometer onto transmission electron microscope grids for cryo-electron microscopy. This system also allows...
6.
Westphall M, Lee K, Salome A, Coon J, Grant T
Curr Opin Struct Biol
. 2023 Sep;
83:102699.
PMID: 37703606
Structure determination by single-particle cryoEM has matured into a core structural biology technique. Despite many methodological advancements, most cryoEM grids are still prepared using the plunge-freezing method developed ∼40 years...
7.
Westphall M, Lee K, Hemme C, Salome A, Mertz K, Grant T, et al.
bioRxiv
. 2023 Jul;
PMID: 37502880
We describe an apparatus for the cryogenic landing of particles from the ion beam of a mass spectrometer onto transmission electron microscope grids for cryo-electron microscopy. This system also allows...
8.
He Y, Shishkova E, Peters-Clarke T, Brademan D, Westphall M, Bergen D, et al.
Anal Chem
. 2023 Jun;
95(28):10655-10663.
PMID: 37389810
Mass spectrometry (MS)-based proteomics is a powerful technology to globally profile protein abundances, activities, interactions, and modifications. The extreme complexity of proteomics samples, which often contain hundreds of thousands of...
9.
Sinitcyn P, Richards A, Weatheritt R, Brademan D, Marx H, Shishkova E, et al.
Nat Biotechnol
. 2023 Mar;
41(12):1776-1786.
PMID: 36959352
An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide sequences representing a small fraction of their total...
10.
Lee K, Salome A, Westphall M, Grant T, Coon J
J Proteome Res
. 2023 Jan;
22(3):851-856.
PMID: 36608276
Addressing mixtures and heterogeneity in structural biology requires approaches that can differentiate and separate structures based on mass and conformation. Mass spectrometry (MS) provides tools for measuring and isolating gas-phase...