Nicholas M Dean
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Explore the profile of Nicholas M Dean including associated specialties, affiliations and a list of published articles.
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33
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1806
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Recent Articles
11.
Perera R, Marcusson E, Koo S, Kang X, Kim Y, White N, et al.
Gene
. 2005 Dec;
369:90-9.
PMID: 16380219
Adipogenesis is the process by which undifferentiated precursor cells differentiate into fat laden adipocytes. The nuclear proteins peroxisome proliferator-activated receptors (PPARs) play a central role in adipocyte differentiation. The goals...
12.
Gysin S, Lee S, Dean N, McMahon M
Cancer Res
. 2005 Jun;
65(11):4870-80.
PMID: 15930308
Expression of mutationally activated RAS is a feature common to the vast majority of human pancreatic adenocarcinomas. RAS elicits its effects through numerous signaling pathways including the RAF-->mitogen-activated protein (MAP)/extracellular...
13.
Sun Y, Koo S, White N, Peralta E, Esau C, Dean N, et al.
Nucleic Acids Res
. 2004 Dec;
32(22):e188.
PMID: 15616155
MicroRNAs (miRNAs) are believed to play important roles in developmental and other cellular processes by hybridizing to complementary target mRNA transcripts. This results in either cleavage of the hybridized transcript...
14.
Esau C, Kang X, Peralta E, Hanson E, Marcusson E, Ravichandran L, et al.
J Biol Chem
. 2004 Oct;
279(50):52361-5.
PMID: 15504739
MicroRNAs (miRNAs) are endogenously expressed 20-24 nucleotide RNAs thought to repress protein translation through binding to a target mRNA (1-3). Only a few of the more than 250 predicted human...
15.
Henry S, Marcusson E, Vincent T, Dean N
Trends Pharmacol Sci
. 2004 Sep;
25(10):523-7.
PMID: 15380936
The application of antisense technology to study physiological and disease processes continues to mature. Antisense approaches are among the most direct means to use genomic sequence information. When developing therapeutics,...
16.
Golden T, Aragon I, Zhou G, Cooper S, Dean N, Honkanen R
Cancer Lett
. 2004 Sep;
215(1):95-100.
PMID: 15374638
Serine/threonine protein phosphatase 5 (PP5) appears to play an underappreciated role in the regulation of cellular proliferation. In estrogen-responsive cells, PP5 expression is stimulated by 17 beta-estradiol, and in a...
17.
Ravichandran L, Dean N, Marcusson E
Oligonucleotides
. 2004 Apr;
14(1):49-64.
PMID: 15104896
With the completion of sequencing of the human genome, a great deal of interest has been shifted toward functional genomics-based research for identification of novel drug targets for treatment of...
18.
Uchio K, Graham M, Dean N, Rosenbaum J, Desmouliere A
Wound Repair Regen
. 2004 Feb;
12(1):60-6.
PMID: 14974966
Transforming growth factor (TGF)-beta 1 is a major mediator of liver fibrosis. Connective tissue growth factor (CTGF) mediates TGF-beta 1 pro-fibrogenic effects in vitro, but its in vivo role is...
19.
Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean N, et al.
Genes Dev
. 2004 Feb;
18(3):249-54.
PMID: 14871926
The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxic stress is only partially understood. Here we...
20.
Dean N, Bennett C
Oncogene
. 2003 Dec;
22(56):9087-96.
PMID: 14663487
There has been steady progress in antisense technology over the past 14 years. We now have a far better appreciation of the attributes and limitations of the technology. Antisense oligonucleotides...