Nicholas J Magon
Overview
Explore the profile of Nicholas J Magon including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
196
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Recent Articles
1.
Smith-Diaz C, Kumar A, Das A, Pace P, Chitcholtan K, Magon N, et al.
Free Radic Biol Med
. 2025 Jan;
229:427-440.
PMID: 39793908
Cutaneous melanoma is a highly invasive, heterogeneous and treatment resistant cancer. It's ability to dynamically shift between transcriptional states or phenotypes results in an adaptive cell plasticity that may drive...
2.
Heath S, Naughton J, Magon N, Gray S, Smith B, Morris V, et al.
J Biol Chem
. 2024 Jul;
300(8):107590.
PMID: 39032649
The human tumor suppressor p16 is a small monomeric protein that can form amyloid structures. Formation of p16 amyloid fibrils is induced by oxidation which creates an intermolecular disulfide bond....
3.
Heath S, Gray S, Hamzah E, OConnor K, Bozonet S, Botha A, et al.
Nat Commun
. 2024 Jul;
15(1):5535.
PMID: 38951545
The conversion of a soluble protein into polymeric amyloid structures is a process that is poorly understood. Here, we describe a fully redox-regulated amyloid system in which cysteine oxidation of...
4.
Topham B, de Vries M, Nonis M, van Berkel R, Pullar J, Magon N, et al.
Epigenomes
. 2024 May;
8(2).
PMID: 38804366
The treatment of metastatic melanoma has been revolutionised by immunotherapy, yet a significant number of patients do not respond, and many experience autoimmune adverse events. Associations have been reported between...
5.
Major G, Longoni A, Simcock J, Magon N, Harte J, Bathish B, et al.
Adv Sci (Weinh)
. 2023 Jul;
10(26):e2300538.
PMID: 37424046
Visible light-mediated cross-linking has utility for enhancing the structural capacity and shape fidelity of laboratory-based polymers. With increased light penetration and cross-linking speed, there is opportunity to extend future applications...
6.
Bozonet S, Magon N, Schwartfeger A, Konigstorfer A, Heath S, Vissers M, et al.
J Biol Chem
. 2023 May;
299(6):104792.
PMID: 37150321
Necroptosis is a form of regulated cell death triggered by various host and pathogen-derived molecules during infection and inflammation. The essential step leading to necroptosis is phosphorylation of the mixed...
7.
Crake R, Burgess E, Wiggins G, Magon N, Das A, Vissers M, et al.
Sci Rep
. 2022 Sep;
12(1):14845.
PMID: 36050369
Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature. 5-hydroxymethylcytosine (5-hmC), an intermediate generated in the demethylation of 5-methylcytosine, is present at reduced levels...
8.
Smyth L, Murray H, Hill M, van Leeuwen E, Highet B, Magon N, et al.
Acta Neuropathol Commun
. 2022 Mar;
10(1):38.
PMID: 35331340
Introduction: Neutrophil accumulation is a well-established feature of Alzheimer's disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high levels of...
9.
Edwards T, Dickerhof N, Magon N, Paton L, Sly P, Kettle A
J Immunol
. 2022 Jan;
208(4):979-990.
PMID: 35046105
Calprotectin is released by activated neutrophils along with myeloperoxidase (MPO) and proteases. It plays numerous roles in inflammation and infection, and is used as an inflammatory biomarker. However, calprotectin is...
10.
Smith-Diaz C, Magon N, McKenzie J, Hampton M, Vissers M, Das A
Front Oncol
. 2021 Sep;
11:709543.
PMID: 34497762
Loss-of-function mutations in the DNA demethylase TET2 are associated with the dysregulation of hematopoietic stem cell differentiation and arise in approximately 10% of acute myeloid leukemia (AML). mutations coexist with...