Andrew G Li
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Explore the profile of Andrew G Li including associated specialties, affiliations and a list of published articles.
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10
Citations
484
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Recent Articles
1.
Marin-Gonzalez A, Rybczynski A, Nilavar N, Nguyen D, Karwacki-Neisius V, Li A, et al.
bioRxiv
. 2025 Feb;
PMID: 39990468
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce formation of chromatin loops, with the break positioned at the loop...
2.
Elango R, Nilavar N, Li A, Nguyen D, Rass E, Duffey E, et al.
Mol Cell
. 2024 Dec;
85(1):78-90.e3.
PMID: 39631396
Replication fork collision with a DNA nick can generate a one-ended break, fostering genomic instability. The opposing fork's collision with the nick could form a second DNA end, enabling conservative...
3.
Elango R, Nilavar N, Li A, Duffey E, Jiang Y, Nguyen D, et al.
bioRxiv
. 2024 Apr;
PMID: 38645103
Collision of a replication fork with a DNA nick is thought to generate a one-ended break, fostering genomic instability. Collision of the opposing converging fork with the nick could, in...
4.
Li A, Murphy E, Culhane A, Powell E, Wang H, Bronson R, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):E9600-E9609.
PMID: 30254159
is an established breast and ovarian tumor suppressor gene that encodes multiple protein products whose individual contributions to human cancer suppression are poorly understood. BRCA1-IRIS (also known as "IRIS"), an...
5.
Wang H, Bierie B, Li A, Pathania S, Toomire K, Dimitrov S, et al.
Mol Cell
. 2016 Jul;
63(2):277-292.
PMID: 27373334
An abnormal differentiation state is common in BRCA1-deficient mammary epithelial cells, but the underlying mechanism is unclear. Here, we report a convergence between DNA repair and normal, cultured human mammary...
6.
Li A, Piluso L, Cai X, Gadd B, Ladurner A, Liu X
Mol Cell
. 2007 Nov;
28(3):408-21.
PMID: 17996705
Posttranslational modifications mediate important regulatory functions in biology. The acetylation of the p53 transcription factor, for example, promotes transcriptional activation of target genes including p21. Here we show that the...
7.
Li A, Piluso L, Cai X, Wei G, Sellers W, Liu X
Mol Cell
. 2006 Aug;
23(4):575-87.
PMID: 16916644
Earlier studies have shown that PTEN regulated p53 protein stability both in a phosphatase-dependent manner through antagonizing Akt-Mdm2 pathway and in a phosphatase-independent manner through interacting with p53. In this...
8.
Piluso L, Wei G, Li A, Liu X
Protein Expr Purif
. 2005 Mar;
40(2):370-8.
PMID: 15766879
As cells persist in their environment, they are exposed to harmful agents that can damage their genomic DNA. When DNA becomes damaged, p53, a tumor suppressor, is stabilized and acts...
9.
Wei G, Li A, Liu X
J Biol Chem
. 2005 Jan;
280(13):12271-8.
PMID: 15661746
As a transcription factor, p53 recognizes a specific consensus DNA sequence and activates the expression of the target genes involved in either growth arrest or apoptosis. Despite our wealth of...
10.
Li H, Li A, Sheppard H, Liu X
Mol Cell
. 2004 Apr;
13(6):867-78.
PMID: 15053879
The largest subunit of TFIID, TAF1, possesses an intrinsic protein kinase activity and is important for cell G1 progression and apoptosis. Since p53 functions by inducing cell G1 arrest and...