Nicholas A Graham
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Explore the profile of Nicholas A Graham including associated specialties, affiliations and a list of published articles.
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46
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1588
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Recent Articles
1.
Mei Y, Gosztyla M, Tan X, Dozier L, Wilkinson B, McKetney J, et al.
Cell Syst
. 2025 Mar;
:101204.
PMID: 40054464
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry...
2.
Tavakoli N, Fong E, Coleman A, Huang Y, Bigger M, Doche M, et al.
NPJ Syst Biol Appl
. 2025 Jan;
11(1):12.
PMID: 39875420
Cancer-associated fibroblasts (CAFs) play a key role in metabolic reprogramming and are well-established contributors to drug resistance in colorectal cancer (CRC). To exploit this metabolic crosstalk, we integrated a systems...
3.
Masterman-Smith M, Graham N, Panosyan E, Mottahedeh J, Samuels E, Nunez A, et al.
Cancer Res Treat
. 2025 Jan;
PMID: 39788641
Purpose: In glioblastoma, the therapeutically intractable and resistant phenotypes can be derived from glioma stem cells, which often have different underlying mechanisms from non-stem glioma cells. Aberrant signaling across the...
4.
Tavakoli N, Fong E, Coleman A, Huang Y, Bigger M, Doche M, et al.
bioRxiv
. 2024 Jun;
PMID: 38826317
Cancer-associated fibroblasts (CAFs) play a key role in metabolic reprogramming and are well-established contributors to drug resistance in colorectal cancer (CRC). To exploit this metabolic crosstalk, we integrated a systems...
5.
Jiang J, Wilkinson B, Flores I, Hartel N, Mihaylov S, Clementel V, et al.
Front Mol Neurosci
. 2024 Apr;
17:1359154.
PMID: 38638602
A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD)...
6.
Kim S, Miller B, Hartel N, Ramirez 2nd R, Braniff R, Leelaprachakul N, et al.
Mol Psychiatry
. 2024 Jan;
29(2):505-517.
PMID: 38167865
Mitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a reduced risk of developing Parkinson's disease (PD), yet the underlying mechanisms remain elusive. In this study, we investigate the...
7.
Garana B, Joly J, Delfarah A, Hong H, Graham N
BMC Bioinformatics
. 2023 May;
24(1):215.
PMID: 37226094
Background: There is a pressing need for improved methods to identify effective therapeutics for diseases. Many computational approaches have been developed to repurpose existing drugs to meet this need. However,...
8.
Jami S, Wilkinson B, Guglietta R, Hartel N, Babiec W, Graham N, et al.
Sci Rep
. 2023 May;
13(1):7493.
PMID: 37161045
Activation of β-adrenergic receptors (β-ARs) not only enhances learning and memory but also facilitates the induction of long-term potentiation (LTP), a form of synaptic plasticity involved in memory formation. To...
9.
Gelbach P, Zheng D, Fraser S, White K, Graham N, Finley S
PLoS Comput Biol
. 2022 Oct;
18(10):e1010555.
PMID: 36251711
Pancreatic β-cells respond to increased extracellular glucose levels by initiating a metabolic shift. That change in metabolism is part of the process of glucose-stimulated insulin secretion and is of particular...
10.
Vanlieshout T, Stouth D, Hartel N, Vasam G, Ng S, Webb E, et al.
Mol Metab
. 2022 Jul;
64:101555.
PMID: 35872306
Objective: Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of arginine residues on target proteins to regulate critical processes in health and disease. A mechanistic understanding of the role(s) of...