Marcelo P Coba
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Explore the profile of Marcelo P Coba including associated specialties, affiliations and a list of published articles.
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27
Citations
1095
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Recent Articles
1.
Mei Y, Gosztyla M, Tan X, Dozier L, Wilkinson B, McKetney J, et al.
Cell Syst
. 2025 Mar;
:101204.
PMID: 40054464
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry...
2.
Chung C, Kou Y, Shemtov S, Verheijen B, Flores I, Love K, et al.
Nat Commun
. 2024 Oct;
15(1):8676.
PMID: 39375347
Aging is characterized by the accumulation of proteins that display amyloid-like behavior. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that amyloid-like proteins are...
3.
Jiang J, Wilkinson B, Flores I, Hartel N, Mihaylov S, Clementel V, et al.
Front Mol Neurosci
. 2024 Apr;
17:1359154.
PMID: 38638602
A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD)...
4.
Atamian A, Birtele M, Hosseini N, Nguyen T, Seth A, Del Dosso A, et al.
Cell Stem Cell
. 2024 Jan;
31(1):39-51.e6.
PMID: 38181749
Research on human cerebellar development and disease has been hampered by the need for a human cell-based system that recapitulates the human cerebellum's cellular diversity and functional features. Here, we...
5.
Birtele M, Del Dosso A, Xu T, Nguyen T, Wilkinson B, Hosseini N, et al.
Nat Neurosci
. 2023 Nov;
26(12):2090-2103.
PMID: 37946050
Genes involved in synaptic function are enriched among those with autism spectrum disorder (ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has been implicated as a convergent mechanism in ASD pathophysiology,...
6.
Jami S, Wilkinson B, Guglietta R, Hartel N, Babiec W, Graham N, et al.
Sci Rep
. 2023 May;
13(1):7493.
PMID: 37161045
Activation of β-adrenergic receptors (β-ARs) not only enhances learning and memory but also facilitates the induction of long-term potentiation (LTP), a form of synaptic plasticity involved in memory formation. To...
7.
Barisano G, Kisler K, Wilkinson B, Nikolakopoulou A, Sagare A, Wang Y, et al.
J Exp Med
. 2022 Aug;
219(11).
PMID: 36040482
Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to blood-brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction predicts cognitive decline and precedes synaptic deficits...
8.
Hurley M, Urra C, Garduno B, Bruno A, Kimbell A, Wilkinson B, et al.
Front Aging Neurosci
. 2022 Jul;
14:894994.
PMID: 35860672
The degu () is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all...
9.
Wilkinson B, Coba M
Cell Signal
. 2020 Sep;
76:109782.
PMID: 32941943
The postsynaptic density (PSD) plays an essential role in the organization of the synaptic signaling machinery. It contains a set of core scaffolding proteins that provide the backbone to PSD...
10.
Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba M, et al.
Neuron
. 2019 Jun;
103(2):217-234.e4.
PMID: 31171447
Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are...