Neil R Clark
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Explore the profile of Neil R Clark including associated specialties, affiliations and a list of published articles.
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21
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4561
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Recent Articles
1.
Grimes M, Hall B, Foltz L, Levy T, Rikova K, Gaiser J, et al.
Sci Signal
. 2018 May;
11(531).
PMID: 29789295
Protein posttranslational modifications (PTMs) have typically been studied independently, yet many proteins are modified by more than one PTM type, and cell signaling pathways somehow integrate this information. We coupled...
2.
Hodos R, Zhang P, Lee H, Duan Q, Wang Z, Clark N, et al.
Pac Symp Biocomput
. 2017 Dec;
23:32-43.
PMID: 29218867
Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. However, limited data availability across cell types...
3.
Duan Q, Reid S, Clark N, Wang Z, Fernandez N, Rouillard A, et al.
NPJ Syst Biol Appl
. 2017 Apr;
2.
PMID: 28413689
The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic...
4.
Wang Z, Monteiro C, Jagodnik K, Fernandez N, Gundersen G, Rouillard A, et al.
Nat Commun
. 2016 Sep;
7:12846.
PMID: 27667448
Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. Here we report...
5.
Morgan D, Poolman T, Williamson A, Wang Z, Clark N, Maayan A, et al.
Sci Rep
. 2016 May;
6:26419.
PMID: 27226058
The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly conserved minor splice variant, GRγ, which differs by a single arginine within the DNA binding domain....
6.
Wang Z, Clark N, Maayan A
Bioinformatics
. 2016 May;
32(15):2338-45.
PMID: 27153606
Motivation: Adverse drug reactions (ADRs) are a central consideration during drug development. Here we present a machine learning classifier to prioritize ADRs for approved drugs and pre-clinical small-molecule compounds by...
7.
Clark N, Szymkiewicz M, Wang Z, Monteiro C, Jones M, Maayan A
Proceedings (IEEE Int Conf Bioinformatics Biomed)
. 2016 Feb;
2015:256-262.
PMID: 26848405
Gene set analysis of differential expression, which identifies collectively differentially expressed gene sets, has become an important tool for biology. The power of this approach lies in its reduction of...
8.
Wang Z, Clark N, Maayan A
BMC Syst Biol
. 2015 Jun;
9:26.
PMID: 26048415
Background: Thousands of biological and biomedical investigators study of the functional role of single genes and their protein products in normal physiology and in disease. The findings from these studies...
9.
Liscio P, Carotti A, Asciutti S, Ferri M, Pires M, Valloscuro S, et al.
Eur J Med Chem
. 2014 Oct;
87:611-23.
PMID: 25299683
A virtual screening procedure was applied to identify new tankyrase inhibitors. Through pharmacophore screening of a compounds collection from the SPECS database, the methoxy[l]benzothieno[2,3-c]quinolin-6(5H)-one scaffold was identified as nicotinamide mimetic...
10.
Maayan A, Rouillard A, Clark N, Wang Z, Duan Q, Kou Y
Trends Pharmacol Sci
. 2014 Aug;
35(9):450-60.
PMID: 25109570
Data sets from recent large-scale projects can be integrated into one unified puzzle that can provide new insights into how drugs and genetic perturbations applied to human cells are linked...