Andrew D Rouillard
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Explore the profile of Andrew D Rouillard including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Edwards J, Rouillard A, Fernandez N, Wang Z, Lachmann A, Shankaran S, et al.
JACC Basic Transl Sci
. 2020 May;
5(4):376-386.
PMID: 32368696
Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with...
2.
Vijayan V, Rouillard A, Rajpal D, Agarwal P
Expert Opin Drug Discov
. 2019 Jan;
14(3):191-194.
PMID: 30696299
No abstract available.
3.
Rouillard A, Hurle M, Agarwal P
PLoS Comput Biol
. 2018 May;
14(5):e1006142.
PMID: 29782487
Target selection is the first and pivotal step in drug discovery. An incorrect choice may not manifest itself for many years after hundreds of millions of research dollars have been...
4.
Duan Q, Reid S, Clark N, Wang Z, Fernandez N, Rouillard A, et al.
NPJ Syst Biol Appl
. 2017 Apr;
2.
PMID: 28413689
The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic...
5.
Nguyen D, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, et al.
Nucleic Acids Res
. 2016 Dec;
45(D1):D995-D1002.
PMID: 27903890
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating...
6.
Wang Z, Monteiro C, Jagodnik K, Fernandez N, Gundersen G, Rouillard A, et al.
Nat Commun
. 2016 Sep;
7:12846.
PMID: 27667448
Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. Here we report...
7.
Rouillard A, Gundersen G, Fernandez N, Wang Z, Monteiro C, McDermott M, et al.
Database (Oxford)
. 2016 Jul;
2016.
PMID: 27374120
Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly generate a plethora of data on the activity and levels of biomolecules within mammalian cells. At the same time, curation projects that...
8.
Kuleshov M, Jones M, Rouillard A, Fernandez N, Duan Q, Wang Z, et al.
Nucleic Acids Res
. 2016 May;
44(W1):W90-7.
PMID: 27141961
Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr....
9.
Rouillard A, Wang Z, Maayan A
Comput Biol Chem
. 2015 Aug;
59 Pt B:123-38.
PMID: 26297300
With advances in genomics, transcriptomics, metabolomics and proteomics, and more expansive electronic clinical record monitoring, as well as advances in computation, we have entered the Big Data era in biomedical...
10.
Rouillard A, Wang Z, Maayan A
Comput Biol Chem
. 2015 Jun;
58:104-19.
PMID: 26101093
No abstract available.