Nathan P Metzger
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Explore the profile of Nathan P Metzger including associated specialties, affiliations and a list of published articles.
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19
Citations
258
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Recent Articles
1.
Varshney S, Shankar K, Kerr H, Anderson L, Gupta D, Metzger N, et al.
Endocrinology
. 2024 Sep;
165(11).
PMID: 39331742
The hormone ghrelin serves a protective role in cancer-related anorexia-cachexia syndrome (CACS)-a condition in which plasma levels of ghrelin rise, its administration lessens CACS severity, and experimentally reduced signaling by...
2.
Gupta D, Burstein A, Schwalbe D, Shankar K, Varshney S, Singh O, et al.
J Clin Invest
. 2024 May;
134(10).
PMID: 38747294
No abstract available.
3.
Shankar K, Metzger N, Lawrence C, Gupta D, Osborne-Lawrence S, Varshney S, et al.
Mol Metab
. 2024 May;
84:101950.
PMID: 38697291
Objective: The number of individuals affected by metabolic dysfunction associated fatty liver disease [1] is on the rise, yet hormonal contributors to the condition remain incompletely described and only a...
4.
Gupta D, Burstein A, Schwalbe D, Shankar K, Varshney S, Singh O, et al.
J Clin Invest
. 2023 Dec;
133(24).
PMID: 38099492
Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here, we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size...
5.
Singh O, Ogden S, Varshney S, Shankar K, Gupta D, Paul S, et al.
JCI Insight
. 2023 Nov;
8(24).
PMID: 37962950
Previous studies have implicated the orexigenic hormone ghrelin as a mediator of exercise endurance and the feeding response postexercise. Specifically, plasma ghrelin levels nearly double in mice when they are...
6.
Shankar K, Varshney S, Gupta D, Mani B, Osborne-Lawrence S, Metzger N, et al.
Front Endocrinol (Lausanne)
. 2023 Jun;
14:1181856.
PMID: 37334290
Introduction: Recurrent episodes of insulin-induced hypoglycemia in patients with diabetes mellitus can result in hypoglycemia-associated autonomic failure (HAAF), which is characterized by a compromised response to hypoglycemia by counterregulatory hormones...
7.
Osborne-Lawrence S, Lawrence C, Metzger N, Klavon J, Baig H, Richard C, et al.
Obesity (Silver Spring)
. 2023 May;
31(6):1644-1654.
PMID: 37161883
Objective: Prader-Willi syndrome (PWS) is a multisystem genetic disorder. Unfortunately, none of several mouse models carrying PWS mutations emulates the entirety of the human PWS phenotype, including hyperphagia plus obesity....
8.
Shankar K, Takemi S, Gupta D, Varshney S, Mani B, Osborne-Lawrence S, et al.
JCI Insight
. 2021 Sep;
6(18).
PMID: 34473648
Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell-selective insulin receptor-KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell-expressed insulin...
9.
Shankar K, Metzger N, Singh O, Mani B, Osborne-Lawrence S, Varshney S, et al.
Mol Metab
. 2021 Aug;
53:101327.
PMID: 34428557
Objective: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases...
10.
Gupta D, Dowsett G, Mani B, Shankar K, Osborne-Lawrence S, Metzger N, et al.
Endocrinology
. 2021 Jul;
162(10).
PMID: 34289060
Islets represent an important site of direct action of the hormone ghrelin, with expression of the ghrelin receptor (growth hormone secretagogue receptor; GHSR) having been localized variably to alpha cells,...