Nathan P Metzger
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Explore the profile of Nathan P Metzger including associated specialties, affiliations and a list of published articles.
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19
Citations
258
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Recent Articles
11.
Gupta D, Patterson A, Osborne-Lawrence S, L Bookout A, Varshney S, Shankar K, et al.
Mol Metab
. 2021 May;
53:101258.
PMID: 34023483
Objective: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions...
12.
Shankar K, Gupta D, Mani B, Findley B, Osborne-Lawrence S, Metzger N, et al.
Front Endocrinol (Lausanne)
. 2020 Oct;
11:606.
PMID: 33042003
Insulin-induced hypoglycemia is a major limiting factor in maintaining optimal blood glucose in patients with type 1 diabetes and advanced type 2 diabetes. Luckily, a counterregulatory response (1) system exists...
13.
Torz L, Osborne-Lawrence S, Rodriguez J, He Z, Cornejo M, Mustafa E, et al.
Mol Metab
. 2020 Apr;
39:101004.
PMID: 32339772
Objective: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent)...
14.
Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia
Shankar K, Gupta D, Mani B, Findley B, Lord C, Osborne-Lawrence S, et al.
Diabetes
. 2019 Nov;
69(2):228-237.
PMID: 31685528
Insulin-induced hypoglycemia leads to far-ranging negative consequences in patients with diabetes. Components of the counterregulatory response (CRR) system that help minimize and reverse hypoglycemia and coordination between those components are...
15.
Mani B, Castorena C, Vianna C, Lee C, Metzger N, Vijayaraghavan P, et al.
Neuroscience
. 2019 Sep;
447:53-62.
PMID: 31520709
Ghrelin administration increases food intake, body weight (BW), adiposity, and blood glucose. In contrast, although mouse models lacking ghrelin or its receptor (Growth Hormone Secretagogue Receptor (GHSR)) exhibit life-threatening hypoglycemia...
16.
Mani B, Puzziferri N, He Z, Rodriguez J, Osborne-Lawrence S, Metzger N, et al.
J Clin Invest
. 2019 Aug;
129(9):3909-3923.
PMID: 31424424
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit...
17.
Gupta D, Chuang J, Mani B, Shankar K, Rodriguez J, Osborne-Lawrence S, et al.
Neuropsychopharmacology
. 2019 Feb;
44(7):1319-1327.
PMID: 30758330
The ghrelin system is a key component of the mood and metabolic responses to chronic psychosocial stress. For example, circulating acyl-ghrelin rises in several rodent and human stress models, administered...
18.
Rodriguez J, Bruggeman E, Mani B, Osborne-Lawrence S, Lord C, Roseman H, et al.
Endocrinology
. 2018 Nov;
159(12):4006-4022.
PMID: 30380028
In the current study, we sought to determine the significance of the ghrelin system in Prader-Willi Syndrome (PWS). PWS is characterized by hypotonia and difficulty feeding in neonates and hyperphagia...
19.
Mani B, Castorena C, Osborne-Lawrence S, Vijayaraghavan P, Metzger N, Elmquist J, et al.
Mol Metab
. 2018 Feb;
9:114-130.
PMID: 29396372
Objective: Exercise training has several well-established health benefits, including many related to body weight, appetite control, and blood glucose homeostasis. However, the molecular mechanisms and, in particular, the hormonal systems...