Jeffrey M Zigman
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Explore the profile of Jeffrey M Zigman including associated specialties, affiliations and a list of published articles.
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108
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5504
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Recent Articles
1.
Zaric V, Kang H, Rybalchenko V, Zigman J, Gray S, Butler R
Genes (Basel)
. 2024 Nov;
15(11).
PMID: 39596566
Background/objectives: Euchromatic histone lysine methyltransferase 2 (EHMT2, also known as G9a) is a mammalian histone methyltransferase that catalyzes the dimethylation of histone 3 lysine 9 (H3K9). On human chromosome 15,...
2.
Varshney S, Shankar K, Kerr H, Anderson L, Gupta D, Metzger N, et al.
Endocrinology
. 2024 Sep;
165(11).
PMID: 39331742
The hormone ghrelin serves a protective role in cancer-related anorexia-cachexia syndrome (CACS)-a condition in which plasma levels of ghrelin rise, its administration lessens CACS severity, and experimentally reduced signaling by...
3.
Stark R, Dempsey H, Kleeman E, Sassi M, Osborne-Lawrence S, Sheybani-Deloui S, et al.
Mol Metab
. 2024 Sep;
89:102025.
PMID: 39236785
Objective: Although the metabolic state of an organism affects olfactory function, the precise mechanisms and their impact on behavior and metabolism remain unknown. Here, we assess whether ghrelin receptors (GHSRs)...
4.
Gupta D, Burstein A, Schwalbe D, Shankar K, Varshney S, Singh O, et al.
J Clin Invest
. 2024 May;
134(10).
PMID: 38747294
No abstract available.
5.
Shankar K, Metzger N, Lawrence C, Gupta D, Osborne-Lawrence S, Varshney S, et al.
Mol Metab
. 2024 May;
84:101950.
PMID: 38697291
Objective: The number of individuals affected by metabolic dysfunction associated fatty liver disease [1] is on the rise, yet hormonal contributors to the condition remain incompletely described and only a...
6.
Nie M, Zhang J, Bal M, Duran C, An S, Zigman J, et al.
Front Physiol
. 2024 Apr;
15:1363708.
PMID: 38638279
Osteoporosis after bariatric surgery is an increasing health concern as the rate of bariatric surgery has risen. In animal studies mimicking bariatric procedures, bone disease, together with decreased serum levels...
7.
Gupta D, Burstein A, Shankar K, Varshney S, Singh O, Osborne-Lawrence S, et al.
Endocrinology
. 2024 Apr;
165(6).
PMID: 38626085
Reducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here we determined if reducing ghrelin also enlarges...
8.
Kulkarni S, Singh O, Zigman J
Nat Rev Endocrinol
. 2023 Dec;
20(4):228-238.
PMID: 38123819
Despite the growing popular interest in sleep and diet, many gaps exist in our scientific understanding of the interaction between circadian rhythms and metabolism. In this Review, we explore a...
9.
Gupta D, Burstein A, Schwalbe D, Shankar K, Varshney S, Singh O, et al.
J Clin Invest
. 2023 Dec;
133(24).
PMID: 38099492
Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here, we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size...
10.
Alex Thomas M, Cui X, Artinian L, Cao Q, Jing J, Silva F, et al.
bioRxiv
. 2023 Dec;
PMID: 38076894
The stomach-derived orexigenic hormone ghrelin is a key regulator of energy homeostasis and metabolism in humans. The ghrelin receptor, growth hormone secretagogue receptor 1a (GHSR), is widely expressed in the...