Nathalie Y R Agar
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Explore the profile of Nathalie Y R Agar including associated specialties, affiliations and a list of published articles.
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99
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3132
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Recent Articles
1.
Yu K, Abou-Mrad Z, Torkenczy K, Schulze I, Gantchev J, Baquer G, et al.
bioRxiv
. 2025 Mar;
PMID: 40027797
Malignant gliomas follow two distinct natural histories: high grade tumors such as glioblastoma, or lower grade tumors with a propensity to transform into high grade disease. Despite differences in tumor...
2.
Venneti S, Kawakibi A, Ji S, Waszak S, Sweha S, Mota M, et al.
Cancer Discov
. 2025 Mar;
15(3):657.
PMID: 40025951
No abstract available.
3.
Hossain M, Brahme R, Miller B, Amin J, de Barros M, Schneider J, et al.
Nat Commun
. 2025 Feb;
16(1):1777.
PMID: 39971904
Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect...
4.
Rendo V, Lee E, Bossi C, Khuu N, Rudek M, Pal S, et al.
Sci Transl Med
. 2025 Feb;
17(786):eadn6274.
PMID: 39970230
Inhibitors of murine double minute homolog 2 (MDM2) represent a promising therapeutic approach for the treatment of wild-type glioblastomas (GBMs), reactivating p53 signaling to induce cancer cell death. We conducted...
5.
Schneider J, Kurmi K, Dai Y, Dhiman I, Joshi S, Gassaway B, et al.
Cell
. 2025 Feb;
188(5):1248-1264.e23.
PMID: 39919745
Little is known about metabolic vulnerabilities in oncogene-driven lung cancer. Here, we perform a phosphoproteomic screen in anaplastic lymphoma kinase (ALK)-rearranged ("ALK+") patient-derived cell lines and identify guanylate kinase 1...
6.
Lee E, Alexander B, Romo C, Supko J, Agar N, Talebi Z, et al.
Clin Cancer Res
. 2025 Jan;
PMID: 39820282
Purpose: Adavosertib is an oral small molecular inhibitor of Wee1. The Adult Brain Tumor Consortium performed a phase I study of adavosertib, radiation (RT) and temozolomide (TMZ) in newly diagnosed...
7.
Vaidya K, Regan M, Lin J, Houle J, Gupta A, Stopka S, et al.
Angew Chem Int Ed Engl
. 2024 Dec;
64(5):e202420052.
PMID: 39714325
We report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with...
8.
Tobochnik S, Regan M, Dorotan M, Reich D, Lapinskas E, Hossain M, et al.
Clin Cancer Res
. 2024 Nov;
30(23):5365-5373.
PMID: 39499201
Purpose: Glutamatergic neuron-glioma synaptogenesis and peritumoral hyperexcitability promote glioma growth in a positive feedback loop. The objective of this study was to evaluate the feasibility and estimated effect sizes of...
9.
Dragojevic S, Smith E, Regan M, Stopka S, Baquer G, Xue Z, et al.
Mol Cancer Ther
. 2024 Oct;
PMID: 39440433
Glioblastoma (GBM) remains one of the most therapy-resistant malignancies with frequent local failures despite aggressive surgery, chemotherapy, and ionizing radiation (IR). Small molecule inhibitors of DNA-dependent protein kinase (DNA-PKi's) are...
10.
Vaidya K, Regan M, Lin J, Houle J, Stopka S, Agar N, et al.
bioRxiv
. 2024 Oct;
PMID: 39386478
We report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with...