David Calligaris
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Explore the profile of David Calligaris including associated specialties, affiliations and a list of published articles.
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32
Citations
1109
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Recent Articles
1.
Zhong A, Muti I, Eyles S, Vachet R, Sikora K, Bobst C, et al.
Front Mol Biosci
. 2022 Apr;
9:785232.
PMID: 35463966
The status of metabolomics as a scientific branch has evolved from proof-of-concept to applications in science, particularly in medical research. To comprehensively evaluate disease metabolomics, multiplatform approaches of NMR combining...
2.
Basu S, Stopka S, Abdelmoula W, Randall E, Lopez B, Regan M, et al.
NPJ Breast Cancer
. 2021 Sep;
7(1):116.
PMID: 34504095
Optimal resection of breast tumors requires removing cancer with a rim of normal tissue while preserving uninvolved regions of the breast. Surgical and pathological techniques that permit rapid molecular characterization...
3.
Randall E, Emdal K, Laramy J, Kim M, Roos A, Calligaris D, et al.
Nat Commun
. 2018 Nov;
9(1):4904.
PMID: 30464169
Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution,...
4.
Clark A, Calligaris D, Regan M, Krummel D, Agar J, Kallay L, et al.
J Neurooncol
. 2018 Aug;
140(2):269-279.
PMID: 30128689
Purpose: Medulloblastoma, the most common primary pediatric malignant brain tumor, originates in the posterior fossa of the brain. Pineoblastoma, which originates within the pineal gland, is a rarer malignancy that...
5.
Kim M, Ma D, Calligaris D, Zhang S, Feathers R, Vaubel R, et al.
Mol Cancer Ther
. 2018 Jul;
17(9):1893-1901.
PMID: 29970480
Controversy exists surrounding whether heterogeneous disruption of the blood-brain barrier (BBB), as seen in glioblastoma (GBM), leads to adequate drug delivery sufficient for efficacy in GBM. This question is especially...
6.
Kim A, Basu S, Glass C, Ross E, Agar N, He Q, et al.
Pain Pract
. 2018 Feb;
18(7):889-894.
PMID: 29480977
Opioids are often used for analgesia via continuous intrathecal delivery by implantable devices. A higher concentration and daily dose of opioid have been postulated as risk factors for intrathecal granuloma...
7.
Braun C, Stanciu M, Boutz P, Patterson J, Calligaris D, Higuchi F, et al.
Cancer Cell
. 2017 Oct;
32(4):411-426.e11.
PMID: 28966034
Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition potently suppresses in ...
8.
Cho C, Wolfe J, Fadzen C, Calligaris D, Hornburg K, Chiocca E, et al.
Nat Commun
. 2017 Jun;
8:15623.
PMID: 28585535
Culture-based blood-brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and permeability remain as major challenges. Here, we...
9.
Sun Y, Alberta J, Pilarz C, Calligaris D, Chadwick E, Ramkissoon S, et al.
Neuro Oncol
. 2017 Jan;
19(6):774-785.
PMID: 28082416
Background: Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However, first-generation RAF inhibitors approved for adult melanoma have poor blood-brain...
10.
Jonas O, Calligaris D, Methuku K, Poe M, Francois J, Tranghese F, et al.
J Biomed Nanotechnol
. 2016 Jun;
12(6):1297-302.
PMID: 27319222
Medulloblastoma is the most common childhood malignant brain tumor. The most lethal medulloblastoma subtype exhibits a high expression of the GABAA receptor α5 subunit gene and MYC amplification. New benzodiazepines...