Narsimha R Penthala
Overview
Explore the profile of Narsimha R Penthala including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
195
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Recent Articles
1.
Darrigues E, Zhao E, De Loose A, Lee M, Borrelli M, Eoff R, et al.
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34639060
Glioblastoma (GBM) is highly resistant to treatment and invasion into the surrounding brain is a cancer hallmark that leads to recurrence despite surgical resection. With the emergence of precision medicine,...
2.
Bowroju S, Penthala N, Lakkaniga N, Balasubramaniam M, Ayyadevara S, Shmookler Reis R, et al.
Bioorg Med Chem
. 2021 Jul;
45:116311.
PMID: 34304133
A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Aβ) aggregation, for...
3.
Penthala N, Balasubramaniam M, Dachavaram S, Morris E, Bhat-Nakshatri P, Ponder J, et al.
Eur J Med Chem
. 2021 Jul;
224:113675.
PMID: 34229108
Melampomagnolide B (MMB, 3) is a parthenolide (PTL, 1) based sesquiterpene lactone that has been used as a template for the synthesis of a plethora of lead anticancer agents owing...
4.
Wang R, Kumar B, Bhat-Nakshatri P, Prasad M, Jacobsen M, Ovalle G, et al.
JCSM Rapid Commun
. 2021 Apr;
4(1):24-39.
PMID: 33842876
Background: Loss of skeletal muscle volume and resulting in functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced MyoD levels and...
5.
Albayati Z, Penthala N, Bommagani S, Post G, Smeltzer M, Crooks P
Toxicol Rep
. 2021 Mar;
8:359-364.
PMID: 33665133
Previous studies have demonstrated that the bone targeting agent BT2-peg2 (BT2-minipeg2, ), when conjugated to vancomycin and delivered systemically by intravenous (IV) or intraperitoneal (IP) injection accumulates in bone to...
6.
Yadlapalli J, Albayati Z, Breen P, Dobretsov M, Penthala N, Hendrickson H, et al.
Drug Dev Res
. 2021 Jan;
82(6):802-814.
PMID: 33427316
Morphine-6-O-sulfate (M6S), a polar, zwitterionic sulfate ester of morphine, is a powerful and safe analgesic in several rat models of pain. A sensitive liquid chromatography-tandem mass spectrometry bioanalytical method was...
7.
Yang J, Williams A, Penthala N, Prather P, Crooks P, Zhan C
ACS Chem Neurosci
. 2020 Sep;
11(20):3455-3463.
PMID: 32997485
The cannabinoid (CB) receptors (CBR and CBR) represent a promising therapeutic target for several indications such as nociception and obesity. The ligands with nonselectivity can be traced to the high...
8.
Bowroju S, Mainali N, Ayyadevara S, Penthala N, Krishnamachari S, Kakraba S, et al.
Molecules
. 2020 Aug;
25(16).
PMID: 32784464
A series of novel hybrid 8-hydroxyquinoline-indole derivatives (, and ) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ aggregation as potential treatments for Alzheimer's disease...
9.
Ketkar A, Maddukuri L, Penthala N, Reed M, Zafar M, Crooks P, et al.
ACS Chem Biol
. 2019 May;
14(6):1337-1351.
PMID: 31082191
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for...
10.
Ford B, Cabanlong C, Tai S, Franks L, Penthala N, Crooks P, et al.
J Pharmacol Exp Ther
. 2019 Mar;
369(2):259-269.
PMID: 30833484
Most cannabinoid 1 receptor (CBR) agonists will signal through both G protein-dependent and -independent pathways in an unbiased manner. Recruitment of -arrestin 2 desensitizes and internalizes receptors, producing tolerance that...