Paul L Prather
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Explore the profile of Paul L Prather including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Janganati V, Salazar P, Parks B, Gorman G, Prather P, Peterson E, et al.
Front Pharmacol
. 2023 May;
14:1123261.
PMID: 37229250
An active metabolite of buprenorphine (), called norbuprenorphine (), is implicated in neonatal opioid withdrawal syndrome when BUP is taken during pregnancy. Therefore, reducing or eliminating metabolism of BUP to...
2.
Crosby S, Ahmed I, Osborn L, Wang Z, Schleiff M, Fantegrossi W, et al.
Metabolites
. 2022 Aug;
12(8).
PMID: 36005645
In 2019, synthetic cannabinoids accounted for more than one-third of new drugs of abuse worldwide; however, assessment of associated health risks is not ethical for controlled and often illegal substances,...
3.
Shoeib A, Benson L, Mu S, MacMillan-Crow L, Prather P
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328467
Cannabinoids exert anti-cancer actions; however, the underlying cytotoxic mechanisms and the cannabinoid receptors (CBRs) involved remain unclear. In this study, CBRs were characterized in several cancer cell lines. Radioligand binding...
4.
Cabanlong C, Russell L, Fantegrossi W, Prather P
Toxicol Sci
. 2022 Feb;
187(1):175-185.
PMID: 35201352
Synthetic cannabinoid receptor agonists (SCRAs) are a large group of abused psychoactive compounds that elicit numerous toxic effects not observed with cannabis, including death. Abuse of third-generation SCRA 5F-MDMB-PINACA (also...
5.
Shoeib A, Yarbrough A, Ford B, Franks L, Urbaniak A, Hensley L, et al.
Life Sci
. 2021 Sep;
285:119993.
PMID: 34592231
Aims: Characterizing cannabinoid receptors (CBRs) expressed in Ewing sarcoma (EWS) cell lines as potential targets for anti-cancer drug development. Main Methods: CBR affinity and function were examined by competitive binding...
6.
Fulo H, Shoeib A, Cabanlong C, Williams A, Zhan C, Prather P, et al.
J Med Chem
. 2021 Apr;
64(9):6381-6396.
PMID: 33887913
Synthetic indole cannabinoids characterized by a 2',2'-dimethylindan-5'-oyl group at the indole C3 position constitute a new class of ligands possessing high affinity for human CB receptors at a nanomolar concentration...
7.
Pinson A, Pouncey D, Schleiff M, Fantegrossi W, Prather P, Radominska-Pandya A, et al.
Molecules
. 2020 Oct;
25(20).
PMID: 33092129
In 2020, nearly one-third of new drugs on the global market were synthetic cannabinoids including the drug of abuse -(1-adamantyl)-1-(5-pentyl)-1-indazole-3-carboxamide (5F-APINACA, 5F-AKB48). Knowledge of 5F-APINACA metabolism provides a critical mechanistic...
8.
Yang J, Williams A, Penthala N, Prather P, Crooks P, Zhan C
ACS Chem Neurosci
. 2020 Sep;
11(20):3455-3463.
PMID: 32997485
The cannabinoid (CB) receptors (CBR and CBR) represent a promising therapeutic target for several indications such as nociception and obesity. The ligands with nonselectivity can be traced to the high...
9.
Penthala N, Shoeib A, Dachavaram S, Cabanlong C, Yang J, Zhan C, et al.
Bioorg Med Chem Lett
. 2020 Sep;
30(22):127501.
PMID: 32882418
A series of N-benzyl-7-azaindolequinuclidinone (7-AIQD) analogs have been synthesized and evaluated for affinity toward CB1 and CB2 cannabinoid receptors and identified as a novel class of cannabinoid receptor ligands. Structure-activity...
10.
Pinson A, Yarbrough A, Bush J, Cabanlong C, Shoeib A, Jackson B, et al.
Pharmacol Biochem Behav
. 2020 May;
195:172949.
PMID: 32413436
AKB48 and its fluorinated derivative 5F-AKB48 are synthetic cannabinoids (SCs) which have caused hospitalizations and deaths in human users. Abuse of SCs is dangerous because users may mistake them for...