Nadim Ajami
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Explore the profile of Nadim Ajami including associated specialties, affiliations and a list of published articles.
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19
Citations
987
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Recent Articles
1.
Farias R, Jiang Y, Levy E, Hwang C, Wang J, Burton E, et al.
BMC Cancer
. 2024 Dec;
24(1):1493.
PMID: 39633321
Background: Gut microbiome modulation is a promising strategy for enhancing the response to immune checkpoint blockade (ICB). Fecal microbiota transplant studies have shown positive signals of improved outcomes in both...
2.
Roland C, Nassif Haddad E, Keung E, Wang W, Lazar A, Lin H, et al.
Nat Cancer
. 2024 Feb;
5(4):625-641.
PMID: 38351182
Based on the demonstrated clinical activity of immune-checkpoint blockade (ICB) in advanced dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS), we conducted a randomized, non-comparative phase 2 trial ( NCT03307616...
3.
Jain R, Hadjigeorgiou A, Harkos C, Mishra A, Morad G, Johnson S, et al.
Res Sq
. 2023 Dec;
PMID: 38076985
The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, there is a gap in our understanding of the underlying mechanisms by which the microbiome...
4.
Baruch E, Nagarajan P, Gleber-Netto F, Rao X, Xie T, Akhter S, et al.
Res Sq
. 2023 Jul;
PMID: 37503252
While the nervous system has reciprocal interactions with both cancer and the immune system, little is known about the potential role of tumor associated nerves (TANs) in modulating anti-tumoral immunity....
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6.
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment
Schwabkey Z, Wiesnoski D, Chang C, Tsai W, Pham D, Ahmed S, et al.
Sci Transl Med
. 2022 Nov;
14(671):eabo3445.
PMID: 36383683
Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant ( = ...
7.
Hahn A, Menk A, Rivadeneira D, Augustin R, Xu M, Li J, et al.
Clin Cancer Res
. 2022 Sep;
29(1):154-164.
PMID: 36166093
Purpose: Overweight/obese (OW/OB) patients with metastatic melanoma unexpectedly have improved outcomes with immune checkpoint inhibitors (ICI) and BRAF-targeted therapies. The mechanism(s) underlying this association remain unclear, thus we assessed the...
8.
Karpinets T, Wu X, Solley T, Alam M, Sims T, Yoshida-Court K, et al.
BMC Cancer
. 2022 Sep;
22(1):945.
PMID: 36050658
Background: Gut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, and increased gut diversity is associated with improved outcomes after treatment. We proposed that functions of...
9.
Nolte Fong J, Miketinas D, Moore L, Nguyen D, Graviss E, Ajami N, et al.
Nutrients
. 2022 Jan;
14(2).
PMID: 35057449
Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive...
10.
Sloane R, White M, Witt R, Banerjee A, Davies M, Han G, et al.
Cancers (Basel)
. 2021 Nov;
13(21).
PMID: 34771465
Metastatic melanoma is a deadly malignancy with poor outcomes historically. Immuno-oncology (IO) agents, targeting immune checkpoint molecules such as cytotoxic T-lymphocyte associated protein-4 (CTLA-4) and programmed cell death-1 (PD-1), have...