Mustafa M Siddiq
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Explore the profile of Mustafa M Siddiq including associated specialties, affiliations and a list of published articles.
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22
Citations
139
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Recent Articles
1.
Hansen J, Xiong Y, Siddiq M, Dhanan P, Hu B, Shewale B, et al.
Nat Commun
. 2024 Sep;
15(1):7968.
PMID: 39261481
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic...
2.
Siddiq M, Johnson N, Zorina Y, Yadaw A, Toro C, Hansen J, et al.
Front Pharmacol
. 2023 Oct;
14:1225759.
PMID: 37799971
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and...
3.
Siddiq M, Toro C, Johnson N, Hansen J, Xiong Y, Mellado W, et al.
Front Mol Neurosci
. 2023 Sep;
16:1183315.
PMID: 37692100
Introduction: Neurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs...
4.
Toro C, De Gasperi R, Aslan A, Johnson N, Siddiq M, Chow C, et al.
bioRxiv
. 2023 Aug;
PMID: 37577656
Spinal cord injury (SCI) results in severe atrophy of skeletal muscle in paralyzed regions, and a decrease in the force generated by muscle per unit of cross-sectional area. Oxidation of...
5.
Toro C, Hansen J, Siddiq M, Johnson K, Cao J, Pero A, et al.
Neurotrauma Rep
. 2023 Aug;
4(1):464-477.
PMID: 37528868
Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE, being present in ∼14% of the population. Clinical reports identify ApoE4 as a genetic risk factor for...
6.
Toro C, Johnson K, Hansen J, Siddiq M, Vasquez W, Zhao W, et al.
Front Cell Neurosci
. 2023 Jul;
17:1163436.
PMID: 37416508
Membrane channels such as those formed by connexins (Cx) and P2X receptors (P2XR) are permeable to calcium ions and other small molecules such as adenosine triphosphate (ATP) and glutamate. Release...
7.
Toro C, Johnson K, Hansen J, Siddiq M, Vasquez W, Zhao W, et al.
bioRxiv
. 2023 Feb;
PMID: 36824813
Membrane channels such as connexins (Cx), pannexins (Panx) and P2X receptors (P2X R) are permeable to calcium ions and other small molecules such as ATP and glutamate. Release of ATP...
8.
Hansen J, Siddiq M, Yadaw A, Tolentino R, Rabinovich V, Jayaraman G, et al.
J Biol Chem
. 2022 Aug;
298(10):102325.
PMID: 35926710
Neurite outgrowth is an integrated whole cell response triggered by the cannabinoid-1 receptor. We sought to identify the many different biochemical pathways that contribute to this whole cell response. To...
9.
Siddiq M, Hannila S, Zorina Y, Nikulina E, Rabinovich V, Hou J, et al.
Brain Commun
. 2022 Jan;
3(4):fcab271.
PMID: 34993473
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Triple knockout mice lacking the major myelin-associated inhibitors do not display spontaneous regeneration after injury, indicating the presence...
10.
Siddiq M, Chan A, Miorin L, Yadaw A, Beaumont K, Kehrer T, et al.
J Virol
. 2021 Oct;
96(2):e0106321.
PMID: 34669512
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System show that substantial numbers of COVID-19 patients without prior heart disease develop cardiac dysfunction. How COVID-19 patients develop...