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Carlos A Toro

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Articles 31
Citations 377
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Recent Articles
1.
Toro C, De Gasperi R, Vanselow K, Harlow L, Johnson K, Aslan A, et al.
Front Physiol . 2024 Nov; 15:1486691. PMID: 39524606
Traumatic spinal cord injury (SCI) results in the disruption of physiological systems below the level of the spinal lesion. Connexin hemichannels (CxHCs) are membrane-bound, non-selective pore proteins that are lost...
2.
Saez J, Burrell J, Cahill C, Cullen D, Devi L, Gilbert R, et al.
Front Pharmacol . 2024 Sep; 15:1427147. PMID: 39346563
Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human...
3.
Vasquez W, Toro C, Cardozo C, Cea L, Saez J
J Physiol . 2024 Aug; PMID: 39173050
A growing body of research has provided evidence that de novo expression of connexin hemichannels and upregulation of pannexin hemichannels (Cx HCs and Panx HCs, respectively) in the cytoplasmic membrane...
4.
Huang J, Awad K, Harlow L, Toro C, Brotto M, Cardozo C
Methods Mol Biol . 2024 Jul; 2816:87-100. PMID: 38977591
Laparotomy (EL) is one of the most common procedures performed among surgical specialties. Previous research demonstrates that surgery is associated with an increased inflammatory response. Low psoas muscle mass and...
5.
De Gasperi R, Csernoch L, Dienes B, Gonczi M, Chakrabarty J, Goeta S, et al.
Elife . 2024 May; 12. PMID: 38695862
Here, we investigated the mechanisms by which aging-related reductions of the levels of in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia....
6.
Burrell J, Vu P, Alcott O, Toro C, Cardozo C, Cullen D
Front Cell Neurosci . 2023 Oct; 17:1240916. PMID: 37829672
Peripheral nerve injury often results in poor functional recovery due to a prolonged period of muscle denervation. In particular, absent axonal contact, denervated muscle can undergo irrevocable atrophy and diminished...
7.
Siddiq M, Johnson N, Zorina Y, Yadaw A, Toro C, Hansen J, et al.
Front Pharmacol . 2023 Oct; 14:1225759. PMID: 37799971
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and...
8.
Siddiq M, Toro C, Johnson N, Hansen J, Xiong Y, Mellado W, et al.
Front Mol Neurosci . 2023 Sep; 16:1183315. PMID: 37692100
Introduction: Neurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs...
9.
Graham Z, Siedlik J, Toro C, Harlow L, Cardozo C
Int J Environ Res Public Health . 2023 Aug; 20(16). PMID: 37623175
Traumatic spinal cord injury (SCI) results in wide-ranging cellular and systemic dysfunction in the acute and chronic time frames after the injury. Chronic SCI has well-described secondary medical consequences while...
10.
Toro C, De Gasperi R, Aslan A, Johnson N, Siddiq M, Chow C, et al.
bioRxiv . 2023 Aug; PMID: 37577656
Spinal cord injury (SCI) results in severe atrophy of skeletal muscle in paralyzed regions, and a decrease in the force generated by muscle per unit of cross-sectional area. Oxidation of...