Rosa E Tolentino
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Explore the profile of Rosa E Tolentino including associated specialties, affiliations and a list of published articles.
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11
Citations
78
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Recent Articles
1.
Hansen J, Xiong Y, Siddiq M, Dhanan P, Hu B, Shewale B, et al.
Nat Commun
. 2024 Sep;
15(1):7968.
PMID: 39261481
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic...
2.
Siddiq M, Johnson N, Zorina Y, Yadaw A, Toro C, Hansen J, et al.
Front Pharmacol
. 2023 Oct;
14:1225759.
PMID: 37799971
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and...
3.
Siddiq M, Toro C, Johnson N, Hansen J, Xiong Y, Mellado W, et al.
Front Mol Neurosci
. 2023 Sep;
16:1183315.
PMID: 37692100
Introduction: Neurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs...
4.
Hansen J, Siddiq M, Yadaw A, Tolentino R, Rabinovich V, Jayaraman G, et al.
J Biol Chem
. 2022 Aug;
298(10):102325.
PMID: 35926710
Neurite outgrowth is an integrated whole cell response triggered by the cannabinoid-1 receptor. We sought to identify the many different biochemical pathways that contribute to this whole cell response. To...
5.
Siddiq M, Hannila S, Zorina Y, Nikulina E, Rabinovich V, Hou J, et al.
Brain Commun
. 2022 Jan;
3(4):fcab271.
PMID: 34993473
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Triple knockout mice lacking the major myelin-associated inhibitors do not display spontaneous regeneration after injury, indicating the presence...
6.
Siddiq M, Chan A, Miorin L, Yadaw A, Beaumont K, Kehrer T, et al.
J Virol
. 2021 Oct;
96(2):e0106321.
PMID: 34669512
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System show that substantial numbers of COVID-19 patients without prior heart disease develop cardiac dysfunction. How COVID-19 patients develop...
7.
Biomechanical Forces Regulate Gene Transcription During Stretch-Mediated Growth of Mammalian Neurons
Loverde J, Tolentino R, Soteropoulos P, Pfister B
Front Neurosci
. 2021 Jan;
14:600136.
PMID: 33408609
At birth, there are 100 billion neurons in the human brain, with functional neural circuits extending through the spine to the epidermis of the feet and toes. Following birth, limbs...
8.
Siddiq M, Chan A, Miorin L, Yadaw A, Beaumont K, Kehrer T, et al.
medRxiv
. 2020 Nov;
PMID: 33200140
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System shows that substantial numbers of COVID-19 patients without prior heart disease develop cardiac dysfunction. How COVID-19 patients develop...
9.
Tavassoly I, Hu Y, Zhao S, Mariottini C, Boran A, Chen Y, et al.
Mol Oncol
. 2019 May;
13(8):1725-1743.
PMID: 31116490
The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop...
10.
Havekes R, Park A, Tolentino R, Bruinenberg V, Tudor J, Lee Y, et al.
J Neurosci
. 2016 Aug;
36(34):8936-46.
PMID: 27559174
Unlabelled: Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key...