Sari S Hannila
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Explore the profile of Sari S Hannila including associated specialties, affiliations and a list of published articles.
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17
Citations
256
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Recent Articles
1.
Siddiq M, Johnson N, Zorina Y, Yadaw A, Toro C, Hansen J, et al.
Front Pharmacol
. 2023 Oct;
14:1225759.
PMID: 37799971
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and...
2.
Stewart V, Cadieux J, Thulasiram M, Douglas T, Drewnik D, Selamat S, et al.
FEBS Lett
. 2022 Sep;
596(22):2952-2973.
PMID: 36102862
Myelin-associated glycoprotein (MAG) and Nogo inhibit neurite outgrowth by binding to receptors such as NgR1, PirB and LRP1, and they have also been shown to induce phosphorylation of Smad2, a...
3.
Siddiq M, Hannila S, Zorina Y, Nikulina E, Rabinovich V, Hou J, et al.
Brain Commun
. 2022 Jan;
3(4):fcab271.
PMID: 34993473
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Triple knockout mice lacking the major myelin-associated inhibitors do not display spontaneous regeneration after injury, indicating the presence...
4.
Douglas T, Hannila S
Biochem Cell Biol
. 2021 Sep;
100(1):1-8.
PMID: 34555292
Secretory leukocyte protease inhibitor (SLPI) is a small but powerful member of the serine protease inhibitor family, which includes proteins such as elafin and α1-antitrypsin. These proteins all have similar...
5.
Alizadeh J, Kochan M, Stewart V, Drewnik D, Hannila S, Ghavami S
Mol Neurobiol
. 2021 Aug;
58(12):6077-6091.
PMID: 34449046
Following spinal cord injury (SCI), reactive astrocytes in the glial scar produce high levels of chondroitin sulfate proteoglycans (CSPGs), which are known to inhibit axonal regeneration. Transforming growth factor beta...
6.
Nikulina E, Gkioka V, Siddiq M, Mellado W, Hilaire M, Cain C, et al.
FEBS Lett
. 2020 Jan;
594(9):1389-1402.
PMID: 31985825
Rap1 is a small GTPase that has been implicated in dendritic development and plasticity. In this study, we investigated the role of Rap1 in axonal growth and its activation in...
7.
He H, Deng K, Siddiq M, Pyie A, Mellado W, Hannila S, et al.
J Neurosci
. 2016 Mar;
36(10):3079-91.
PMID: 26961960
Inhibitory molecules associated with CNS myelin, such as myelin-associated glycoprotein (MAG), represent major obstacles to axonal regeneration following CNS injury. Our laboratory has shown that elevating levels of intracellular cAMP,...
8.
Siddiq M, Hannila S
Front Mol Neurosci
. 2015 Jul;
8:26.
PMID: 26150769
Elevation of intracellular cyclic AMP (cAMP) levels has proven to be one of the most effective means of overcoming inhibition of axonal regeneration by myelin-associated inhibitors such as myelin-associated glycoprotein...
9.
Siddiq M, Hannila S, Carmel J, Bryson J, Hou J, Nikulina E, et al.
J Biol Chem
. 2015 May;
290(26):16343-56.
PMID: 25947372
The adult CNS does not spontaneously regenerate after injury, due in large part to myelin-associated inhibitors such as myelin-associated glycoprotein (MAG), Nogo-A, and oligodendrocyte-myelin glycoprotein. All three inhibitors can interact...
10.
Jahan N, Hannila S
Exp Neurol
. 2014 Dec;
263:372-84.
PMID: 25446723
The expression of chondroitin sulfate proteoglycans (CSPGs) by reactive astrocytes is a major factor contributing to glial scarring and regenerative failure after spinal cord injury, but the molecular mechanisms underlying...