Musleh M Muthana
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Explore the profile of Musleh M Muthana including associated specialties, affiliations and a list of published articles.
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18
Citations
292
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Recent Articles
1.
Muthana M, Du X, Liu M, Wang X, Wu W, Ai C, et al.
Elife
. 2023 Dec;
12.
PMID: 38127423
Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3 Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells....
2.
Muthana M, Du X, Liu M, Wang X, Wu W, Ai C, et al.
bioRxiv
. 2023 Mar;
PMID: 36909522
Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3 Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells....
3.
Liu M, Wang X, Du X, Wu W, Zhang Y, Zhang P, et al.
Sci Transl Med
. 2023 Mar;
15(685):eabm5663.
PMID: 36857433
Immune checkpoint inhibitors (ICIs), such as nivolumab and ipilimumab, not only elicit antitumor responses in a wide range of human cancers but also cause severe immune-related adverse events (irAEs), including...
4.
Zhang X, Liu H, He J, Ou C, Donahue T, Muthana M, et al.
ACS Chem Biol
. 2022 Mar;
17(11):3013-3023.
PMID: 35316032
Lysosome-targeting chimeras (LYTACs) offer an opportunity for the degradation of extracellular and membrane-associated proteins of interest. Here, we report an efficient chemoenzymatic method that enables a single-step and site-specific conjugation...
5.
Martinez O, Mahoney B, Goring A, Yi S, Tran D, Cascio D, et al.
J Biol Chem
. 2021 Dec;
298(2):101464.
PMID: 34864059
Wall teichoic acid (WTA) polymers are covalently affixed to the Gram-positive bacterial cell wall and have important functions in cell elongation, cell morphology, biofilm formation, and β-lactam antibiotic resistance. The...
6.
Xu B, Yuan L, Chen G, Li T, Zhou J, Zhang C, et al.
Cancer Cell Int
. 2019 Dec;
19:322.
PMID: 31827396
Background: Autologous tumor-infiltrating lymphocytes (Tils) immunotherapy is a promising treatment in patients with advanced hepatocellular cancer. Although Tils treatment has shown great promise, their persistence and the efficacy after adoptive-transfer...
7.
Li W, Santra A, Yu H, Slack T, Muthana M, Shi D, et al.
J Org Chem
. 2019 May;
84(11):6697-6708.
PMID: 31083938
A library of 2(a),3(a/e)-difluorosialic acids and their C-5 and/or C-9 derivatives were chemoenzymatically synthesized. Pasteurella multocida sialic acid aldolase (PmAldolase), but not its Escherichia coli homologue (EcAldolase), was found to...
8.
Santra A, Yu H, Tasnima N, Muthana M, Li Y, Zeng J, et al.
Chem Sci
. 2017 Feb;
7(4):2827-2831.
PMID: 28138383
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes. Taking advantage...
9.
Li Y, Xue M, Sheng X, Yu H, Zeng J, Thon V, et al.
Bioorg Med Chem
. 2016 Mar;
24(8):1696-705.
PMID: 26968649
β1-3-N-Acetylglucosaminyltransferases (β3GlcNAcTs) and β1-4-galactosyltransferases (β4GalTs) have been broadly used in enzymatic synthesis of N-acetyllactosamine (LacNAc)-containing oligosaccharides and glycoconjugates including poly-LacNAc, and lacto-N-neotetraose (LNnT) found in the milk of human and...
10.
Zhang L, Muthana M, Yu H, McArthur J, Qu J, Chen X
Carbohydr Res
. 2015 Nov;
419:18-28.
PMID: 26598987
Neisseria meningitidis serogroup A non-hydrolyzing uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase (NmSacA) catalyzes the interconversion between UDP-GlcNAc and uridine 5'-diphosphate-N-acetylmannosamine (UDP-ManNAc). It is a key enzyme involved in the biosynthesis of the...