Mojgan Aghazadeh Tabrizi
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Explore the profile of Mojgan Aghazadeh Tabrizi including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Aghazadeh Tabrizi M, Baraldi P, Baraldi S, Prencipe F, Preti D, Saponaro G, et al.
Med Chem
. 2014 Dec;
11(4):342-53.
PMID: 25494808
A series of 1,3,6-triphenylpyrazolo[3,4-b]pyridin-4-one derivatives was designed, synthesized and evaluated for cytotoxic activity in A375 human melanoma and human erythroleukemia (HEL) cells. The new pyrazolopyridones displayed comparable activities to the...
12.
Borea P, Varani K, Vincenzi F, Baraldi P, Aghazadeh Tabrizi M, Merighi S, et al.
Pharmacol Rev
. 2014 Nov;
67(1):74-102.
PMID: 25387804
By general consensus, the omnipresent purine nucleoside adenosine is considered a major regulator of local tissue function, especially when energy supply fails to meet cellular energy demand. Adenosine mediation involves...
13.
Romagnoli R, Baraldi P, IJzerman A, Massink A, Cruz-Lopez O, Lopez-Cara L, et al.
J Med Chem
. 2014 Sep;
57(18):7673-86.
PMID: 25181013
A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or...
14.
Romagnoli R, Baraldi P, Lopez-Cara C, Salvador M, Preti D, Aghazadeh Tabrizi M, et al.
Bioorg Med Chem
. 2014 Jan;
22(18):5097-109.
PMID: 24398384
In search of new compounds with strong antiproliferative activity and simple molecular structure, we designed a novel series of agents based on the 2-amino-3-alkoxycarbonyl/cyano-5-arylethylthiophene scaffold. The presence of the ethyl...
15.
Romagnoli R, Baraldi P, Carrion M, Cruz-Lopez O, Cara C, Saponaro G, et al.
Bioorg Med Chem
. 2013 Dec;
22(1):148-66.
PMID: 24332652
2-Amino-3-benzoyl thiophenes have been widely reported to act as allosteric enhancers at the A1 adenosine receptor. Their activity can be increased considerably by appropriate substitutions at the 4- and 5-positions...
16.
Romagnoli R, Baraldi P, Lopez-Cara C, Preti D, Aghazadeh Tabrizi M, Balzarini J, et al.
J Med Chem
. 2013 Oct;
56(22):9296-309.
PMID: 24164557
The biological importance of microtubules make them an interesting target for the synthesis of antitumor agents. The 2-(3',4',5'-trimethoxybenzoyl)-5-aminobenzo[b]thiophene moiety was identified as a novel scaffold for the preparation of potent...
17.
Romagnoli R, Baraldi P, Carrion M, Cara C, Salvador M, Preti D, et al.
Eur J Med Chem
. 2013 Aug;
67:409-27.
PMID: 23911855
Allosteric enhancers for the A1 adenosine receptor represent a novel and unique drug design strategy to augment the response to endogenous adenosine in a site- and event-specific manner. We have...
18.
Aghazadeh Tabrizi M, Baraldi P, Saponaro G, Moorman A, Romagnoli R, Preti D, et al.
J Med Chem
. 2013 May;
56(11):4482-96.
PMID: 23697626
We recently described the medicinal chemistry of a new series of heteroaryl-4-oxopyridine/7-oxopyrimidines as CB2 receptor partial agonists, showing that the functionality of these ligands is controlled by the nature of...
19.
Vincenzi F, Targa M, Corciulo C, Aghazadeh Tabrizi M, Merighi S, Gessi S, et al.
Pain
. 2013 Mar;
154(6):864-73.
PMID: 23518609
Cannabinoid CB(2) receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of inflammatory, neuropathic, and bone cancer pain. In this study the effect of...
20.
Romagnoli R, Baraldi P, Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, et al.
J Med Chem
. 2013 Mar;
56(6):2606-18.
PMID: 23445496
Two new series of inhibitors of tubulin polymerization based on the 2-(alkoxycarbonyl)-3-(3',4',5'-trimethoxyanilino)benzo[b]thiophene and thieno[2,3-b]pyridine molecular skeletons were synthesized and evaluated for antiproliferative activity on a panel of cancer cell lines,...