Allan R Moorman
Overview
Explore the profile of Allan R Moorman including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
34
Citations
236
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Romagnoli R, Baraldi P, Moorman A, Borea P, Varani K
Future Med Chem
. 2015 Jul;
7(10):1247-59.
PMID: 26144263
Adenosine is an ubiquitous nucleoside involved in various physiological and pathological functions by stimulating A1, A2A, A2B and A3 adenosine receptors (ARs). Allosteric enhancers to A1ARs may represent novel therapeutic...
2.
Romagnoli R, Baraldi P, Lopez-Cara C, Cruz-Lopez O, Moorman A, Massink A, et al.
Eur J Med Chem
. 2015 Jul;
101:185-204.
PMID: 26141910
The 2-amino-3-(p-chlorobenzoyl)thiophene scaffold has been widely employed as a pharmacophore for the identification of small molecules acting as allosteric modulators at the adenosine A1 receptor. A new series of 2-amino-3-(p-chlorobenzoyl)-4-benzyl-5-arylthiophene...
3.
Preti D, Baraldi P, Moorman A, Borea P, Varani K
Med Res Rev
. 2015 Mar;
35(4):790-848.
PMID: 25821194
Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in various physiological and pathological...
4.
Romagnoli R, Baraldi P, IJzerman A, Massink A, Cruz-Lopez O, Lopez-Cara L, et al.
J Med Chem
. 2014 Sep;
57(18):7673-86.
PMID: 25181013
A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or...
5.
Romagnoli R, Baraldi P, Carrion M, Cruz-Lopez O, Cara C, Saponaro G, et al.
Bioorg Med Chem
. 2013 Dec;
22(1):148-66.
PMID: 24332652
2-Amino-3-benzoyl thiophenes have been widely reported to act as allosteric enhancers at the A1 adenosine receptor. Their activity can be increased considerably by appropriate substitutions at the 4- and 5-positions...
6.
Romagnoli R, Baraldi P, Carrion M, Cara C, Salvador M, Preti D, et al.
Eur J Med Chem
. 2013 Aug;
67:409-27.
PMID: 23911855
Allosteric enhancers for the A1 adenosine receptor represent a novel and unique drug design strategy to augment the response to endogenous adenosine in a site- and event-specific manner. We have...
7.
Aghazadeh Tabrizi M, Baraldi P, Saponaro G, Moorman A, Romagnoli R, Preti D, et al.
J Med Chem
. 2013 May;
56(11):4482-96.
PMID: 23697626
We recently described the medicinal chemistry of a new series of heteroaryl-4-oxopyridine/7-oxopyrimidines as CB2 receptor partial agonists, showing that the functionality of these ligands is controlled by the nature of...
8.
Aghazadeh Tabrizi M, Baraldi P, Saponaro G, Moorman A, Romagnoli R, Preti D, et al.
J Med Chem
. 2013 Jan;
56(3):1098-112.
PMID: 23350768
Recent developments indicate that CB(2) receptor ligands have the potential to become therapeutically important. To explore this potential, it is necessary to develop compounds with high affinity for the CB(2)...
9.
Tse S, Powell K, Maclennan S, Moorman A, Paterson C, Bell R
J Pain Res
. 2012 Nov;
5:401-8.
PMID: 23166444
Purpose: This study compared the pharmacokinetic profile, and systemic and local absorption of diclofenac, following dermal patch application and oral administration in Yorkshire-Landrace pigs. Patients And Methods: Twelve anesthetized, female,...
10.
Romagnoli R, Baraldi P, Carrion M, Cara C, Cruz-Lopez O, Salvador M, et al.
J Med Chem
. 2012 Aug;
55(17):7719-35.
PMID: 22889387
We have recently reported a detailed structure-activity relationship study around a wide series of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]thiophene derivatives as potent allosteric enhancers of the A(1) adenosine receptor. In the current study, we...