Mitsutoshi Toyama
Overview
Explore the profile of Mitsutoshi Toyama including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
460
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Recent Articles
1.
Niwa H, Handa N, Tomabechi Y, Honda K, Toyama M, Ohsawa N, et al.
Acta Crystallogr D Biol Crystallogr
. 2013 Mar;
69(Pt 4):595-602.
PMID: 23519668
SET7/9 is a protein lysine methyltransferase that methylates histone H3 and nonhistone proteins such as p53, TAF10 and oestrogen receptor α. In previous work, novel inhibitors of SET7/9 that are...
2.
Tokmakov A, Kurotani A, Takagi T, Toyama M, Shirouzu M, Fukami Y, et al.
J Biol Chem
. 2012 Jun;
287(32):27106-16.
PMID: 22674579
Post-translational modifications (PTMs) are required for proper folding of many proteins. The low capacity for PTMs hinders the production of heterologous proteins in the widely used prokaryotic systems of protein...
3.
Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, et al.
Acta Crystallogr D Biol Crystallogr
. 2011 May;
67(Pt 5):480-7.
PMID: 21543851
AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a sensor to maintain energy balance at both the cellular and the whole-body levels and is therefore a potential...
4.
Rahman S, Ishizuka-Katsura Y, Arai S, Saijo S, Yamato I, Toyama M, et al.
Protein Expr Purif
. 2011 Mar;
78(2):181-8.
PMID: 21356312
The vacuolar-type H+-ATPase (V-ATPase) is a multi-subunit proton pump that is involved in both intra- and extracellular acidification processes throughout human body. Subunits constituting the peripheral stalk of the V-ATPase...
5.
Kurotani A, Takagi T, Toyama M, Shirouzu M, Yokoyama S, Fukami Y, et al.
FASEB J
. 2009 Nov;
24(4):1095-104.
PMID: 19940260
High-throughput cell-free protein synthesis is being used increasingly in structural/functional genomics projects. However, the factors determining expression success are poorly understood. Here, we evaluated the expression of 3066 human proteins...
6.
Arai S, Yamato I, Shiokawa A, Saijo S, Kakinuma Y, Ishizuka-Katsura Y, et al.
Biochem Biophys Res Commun
. 2009 Oct;
390(3):698-702.
PMID: 19833097
Enterococcus hirae vacuolar ATPase (V-ATPase) is composed of a soluble catalytic domain (V(1); NtpA(3)-B(3)-D-G) and an integral membrane domain (V(0); NtpI-K(10)) connected by a central and peripheral stalk(s) (NtpC and...
7.
Arai R, Murayama K, Uchikubo-Kamo T, Nishimoto M, Toyama M, Kuramitsu S, et al.
J Struct Biol
. 2009 Jul;
168(3):575-81.
PMID: 19602440
In many microorganisms, menaquinone is an essential lipid-soluble electron carrier. Recently, an alternative menaquinone biosynthetic pathway was found in some microorganisms [Hiratsuka, T., Furihata, K., Ishikawa, J., Yamashita, H., Itoh,...
8.
Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, et al.
Protein Sci
. 2008 Aug;
17(11):1907-14.
PMID: 18725456
Receptor activity-modifying protein (RAMP) 1 forms a heterodimer with calcitonin receptor-like receptor (CRLR) and regulates its transport to the cell surface. The CRLR.RAMP1 heterodimer functions as a specific receptor for...
9.
Handa N, Mizohata E, Kishishita S, Toyama M, Morita S, Uchikubo-Kamo T, et al.
J Biol Chem
. 2008 May;
283(28):19657-64.
PMID: 18477562
Cyclic nucleotide phosphodiesterases (PDEs) catalyze the degradation of the cyclic nucleotides cAMP and cGMP, which are important second messengers. Five of the 11 mammalian PDE families have tandem GAF domains...
10.
Yamamoto M, Unzai S, Saijo S, Ito K, Mizutani K, Suno-Ikeda C, et al.
J Biol Chem
. 2008 May;
283(28):19422-31.
PMID: 18460472
The vacuolar ATPase (V-ATPase) is composed of a soluble catalytic domain and an integral membrane domain connected by a central stalk and a few peripheral stalks. The number and arrangement...