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Shigeyuki Yokoyama

Explore the profile of Shigeyuki Yokoyama including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 764
Citations 19302
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Chemistry
Top 10 Co-Authors
Mikako Shirouzu
Takaho Terada
Seiki Kuramitsu
Takanori Kigawa
Akiko Tanaka
Kensaku Sakamoto
Shun-Ichi Sekine
Makoto Inoue
Takashi Umehara
Ichiro Hirao
Published In
J Biol Chem
Acta Crystallogr Sect F Struct Biol Cryst Commun
J Mol Biol
Acta Crystallogr D Biol Crystallogr
Protein Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Structural basis for the effects of Ser387 phosphorylation of MgcRacGAP on its GTPase-activating activities for CDC42 and RHOA
Murayama K, Kato-Murayama M, Hosaka T, Kitamura T, Yokoyama S, Shirouzu M
J Struct Biol . 2024 Nov; 216(4):108151. PMID: 39522789
MgcRacGAP is a GTPase-activating protein (GAP) for the Rho family GTPases. During cytokinesis, MgcRacGAP localizes to the midbody, where it activates the GTPase activity of Rho family GTPases to facilitate...
2.
EVA1-antibody drug conjugate is a new therapeutic strategy for eliminating glioblastoma-initiating cells
Hou J, Uejima T, Tanaka M, Son Y, Hanada K, Kukimoto-Niino M, et al.
Neuro Oncol . 2024 Oct; 27(3):682-694. PMID: 39470407
Background: The discovery of glioblastoma (GBM)-initiating cells (GICs) has impacted GBM research. These cells are not only tumorigenic but also exhibit resistance to radiotherapy and chemotherapy. Therefore, it is crucial...
3.
Site-specific photo-crosslinking of Hsc70 with the KFERQ pentapeptide motif in a chaperone-mediated autophagy and microautophagy substrate in mammalian cells
Seike T, Terasawa K, Iwata T, Guan J, Watabe T, Yokoyama S, et al.
Biochem Biophys Res Commun . 2024 Aug; 736:150515. PMID: 39128268
Heat shock cognate protein 70 (Hsc70/HSPA8) belongs to the Hsp70 family of molecular chaperones. The fundamental functions of Hsp70 family molecular chaperones depend on ATP-dependent allosteric regulation of binding and...
4.
Protein-Protein Interface Identification by Site-Specific Photo-Cross-linking/Cleavage in Mammalian Cells
Terasawa K, Seike T, Sakamoto K, Ohtake K, Watabe T, Yokoyama S, et al.
Curr Protoc . 2024 Aug; 4(8):e1103. PMID: 39105689
Identification of protein-protein interfaces is necessary for understanding and regulating biological events. Genetic code expansion enables site-specific photo-cross-linking by introducing photo-reactive non-canonical amino acids into proteins at defined positions during...
5.
Serum anti‑KIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases
Hiwasa T, Yoshida Y, Kubota M, Li S, Zhang B, Matsutani T, et al.
Med Int (Lond) . 2024 Jul; 4(5):45. PMID: 38983794
Numerous antibody biomarkers have been reported for cancer and atherosclerosis-related diseases. The major complications of atherosclerosis and diabetes mellitus (DM) are acute ischemic stroke (AIS), cardiovascular disease (CVD) and chronic...
6.
H, C, and N resonance assignments and solution structure of the N-terminal divergent calponin homology (NN-CH) domain of human intraflagellar transport protein 54
Kuwasako K, Dang W, He F, Takahashi M, Tsuda K, Nagata T, et al.
Biomol NMR Assign . 2024 Mar; 18(1):71-78. PMID: 38551798
The intraflagellar transport (IFT) machinery plays a crucial role in the bidirectional trafficking of components necessary for ciliary signaling, such as the Hedgehog, Wnt/PCR, and cAMP/PKA systems. Defects in some...
7.
A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction
Aizawa K, Ikeda A, Tomida S, Hino K, Sugita Y, Hirose T, et al.
Cells . 2024 Jan; 13(1). PMID: 38201291
Heart failure with reduced ejection fraction (HFrEF) is characterized not only by reduced left ventricular ejection fraction (EF) but is also combined with symptoms such as dyspnea, fatigue, and edema....
8.
Site-specific photo-crosslinking/cleavage for protein-protein interface identification reveals oligomeric assembly of lysosomal-associated membrane protein type 2A in mammalian cells
Terasawa K, Seike T, Sakamoto K, Ohtake K, Terada T, Iwata T, et al.
Protein Sci . 2023 Oct; 32(12):e4823. PMID: 37906694
Genetic code expansion enables site-specific photo-crosslinking by introducing photo-reactive non-canonical amino acids into proteins at defined positions during translation. This technology is widely used for analyzing protein-protein interactions and is...
9.
Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5
Kusano S, Ueda S, Oryoji D, Toyoumi A, Hashimoto-Tane A, Kishi H, et al.
Int Immunol . 2023 Jul; 35(9):447-458. PMID: 37418020
Cry j 1 is a major allergen present in Japanese cedar (Cryptomeria japonica) pollens. Peptides with the core sequence of KVTVAFNQF from Cry j 1 ('pCj1') bind to HLA-DP5 and...
10.
Crystal Structure of Pyrrolysyl-tRNA Synthetase from a Methanogenic Archaeon ISO4-G1 and Its Structure-Based Engineering for Highly-Productive Cell-Free Genetic Code Expansion with Non-Canonical Amino Acids
Yanagisawa T, Seki E, Tanabe H, Fujii Y, Sakamoto K, Yokoyama S
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047230
Pairs of pyrrolysyl-tRNA synthetase (PylRS) and tRNA from and are widely used for site-specific incorporations of non-canonical amino acids into proteins (genetic code expansion). Previously, we achieved full productivity of...