Mikako Shirouzu
Overview
Explore the profile of Mikako Shirouzu including associated specialties, affiliations and a list of published articles.
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388
Citations
8285
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Recent Articles
1.
Naganuma M, Kujirai T, Ehara H, Uejima T, Ito T, Goto M, et al.
Sci Adv
. 2025 Mar;
11(10):eadu0577.
PMID: 40043114
The metazoan transcription elongation complex (EC) of RNA polymerase II (RNAPII) generally stalls between the transcription start site and the first (+1) nucleosome. This promoter-proximal pausing involves negative elongation factor...
2.
Watanabe-Matsui M, Kadoya S, Segawa K, Shima H, Nakagawa T, Nagasawa Y, et al.
iScience
. 2025 Jan;
28(1):111529.
PMID: 39758820
Heme is known to bind to the intrinsically disordered region (IDR) to regulate protein function. The binding of heme to the IDR of transcription factor BACH2 promotes plasma cell differentiation,...
3.
Dileep K, Sakai N, Ihara K, Nakata A, Ito A, Sivaraman D, et al.
Int J Biol Macromol
. 2024 Dec;
293:139320.
PMID: 39740711
The formation of the pyroglutamate variant of amyloid beta (pGlu-Aβ), which is extremely hydrophobic, rapidly aggregating, and highly neurotoxic, is mediated by the action of secretory glutaminyl cyclase (sQC). The...
4.
Koze H, Sudoh M, Onitsuka S, Okamura H, Ishikawa T, Tani F, et al.
J Nat Med
. 2024 Nov;
79(1):122-133.
PMID: 39585602
The persistence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new mutant strains continue to present a substantial threat with potential for future pandemics....
5.
Murayama K, Kato-Murayama M, Hosaka T, Kitamura T, Yokoyama S, Shirouzu M
J Struct Biol
. 2024 Nov;
216(4):108151.
PMID: 39522789
MgcRacGAP is a GTPase-activating protein (GAP) for the Rho family GTPases. During cytokinesis, MgcRacGAP localizes to the midbody, where it activates the GTPase activity of Rho family GTPases to facilitate...
6.
Hasegawa-Takano M, Hosaka T, Kojima K, Nishimura Y, Kurihara M, Nakajima Y, et al.
ISME J
. 2024 Nov;
18(1).
PMID: 39485071
Microbial rhodopsins are prevalent in many cyanobacterial groups as a light-energy-harvesting system in addition to the photosynthetic system. It has been suggested that this dual system allows efficient capture of...
7.
Hou J, Uejima T, Tanaka M, Son Y, Hanada K, Kukimoto-Niino M, et al.
Neuro Oncol
. 2024 Oct;
27(3):682-694.
PMID: 39470407
Background: The discovery of glioblastoma (GBM)-initiating cells (GICs) has impacted GBM research. These cells are not only tumorigenic but also exhibit resistance to radiotherapy and chemotherapy. Therefore, it is crucial...
8.
Miyauchi K, Kimura S, Akiyama N, Inoue K, Ishiguro K, Vu T, et al.
Nat Chem Biol
. 2024 Sep;
PMID: 39300229
Modified tRNA anticodons are critical for proper mRNA translation during protein synthesis. It is generally thought that almost all bacterial tRNAs use a modified cytidine-lysidine (L)-at the first position (34)...
9.
Tehrani M, Matsuda I, Yamagata A, Kodama Y, Matsunaga T, Sato M, et al.
Nat Commun
. 2024 Aug;
15(1):7045.
PMID: 39147751
Arctic (E22G) mutation in amyloid-β (Aβ enhances Aβ40 fibril accumulation in Alzheimer's disease (AD). Unlike sporadic AD, familial AD (FAD) patients with the mutation exhibit more Aβ40 in the plaque...
10.
Serum anti‑KIAA0513 antibody as a common biomarker for mortal atherosclerotic and cancerous diseases
Hiwasa T, Yoshida Y, Kubota M, Li S, Zhang B, Matsutani T, et al.
Med Int (Lond)
. 2024 Jul;
4(5):45.
PMID: 38983794
Numerous antibody biomarkers have been reported for cancer and atherosclerosis-related diseases. The major complications of atherosclerosis and diabetes mellitus (DM) are acute ischemic stroke (AIS), cardiovascular disease (CVD) and chronic...