Robert J Ardecky
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Explore the profile of Robert J Ardecky including associated specialties, affiliations and a list of published articles.
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20
Citations
270
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Recent Articles
1.
Stanford S, Diaz M, Ardecky R, Zou J, Roosild T, Holmes Z, et al.
J Med Chem
. 2021 Apr;
64(9):5645-5653.
PMID: 33914534
Obesity-associated insulin resistance plays a central role in the pathogenesis of type 2 diabetes. A promising approach to decrease insulin resistance in obesity is to inhibit the protein tyrosine phosphatases...
2.
Iizuka S, Quintavalle M, Navarro J, Gribbin K, Ardecky R, Abelman M, et al.
Cancer Res
. 2021 Jan;
81(6):1472-1485.
PMID: 33414172
Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening assay to identify kinases whose activity affects invadopodia formation....
3.
Pinkerton A, Peddibhotla S, Yamamoto F, Slosky L, Bai Y, Maloney P, et al.
J Med Chem
. 2019 Aug;
62(17):8357-8363.
PMID: 31390201
Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated...
4.
Masyuk T, Masyuk A, Lorenzo Pisarello M, Howard B, Huang B, Lee P, et al.
Hepatology
. 2017 May;
66(4):1197-1218.
PMID: 28543567
Conclusion: TGR5 contributes to hepatic cystogenesis by increasing cAMP and enhancing cholangiocyte proliferation; our data suggest that a TGR5 antagonist alone or concurrently with somatostatin receptor agonists represents a potential...
5.
Stanford S, Aleshin A, Zhang V, Ardecky R, Hedrick M, Zou J, et al.
Nat Chem Biol
. 2017 Mar;
13(6):624-632.
PMID: 28346406
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase...
6.
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
Welsh K, Milutinovic S, Ardecky R, Gonzalez-Lopez M, Ganji S, Teriete P, et al.
PLoS One
. 2016 Sep;
11(9):e0161952.
PMID: 27617834
Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines....
7.
Ardecky R, Bobkova E, Kiffer-Moreira T, Brown B, Ganji S, Zou J, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(3):1000-1004.
PMID: 24412070
Alkaline phosphatase (AP) isozymes are present in a wide range of species from bacteria to man and are capable of dephosphorylation and transphosphorylation of a wide spectrum of substrates in...
8.
Finlay D, Vamos M, Gonzalez-Lopez M, Ardecky R, Ganji S, Yuan H, et al.
Mol Cancer Ther
. 2013 Nov;
13(1):5-15.
PMID: 24194568
TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it shows apoptosis-inducing activity in transformed, but not in normal, cells. As with most anticancer agents, however, its clinical use...
9.
Ardecky R, Welsh K, Finlay D, Lee P, Gonzalez-Lopez M, Ganji S, et al.
Bioorg Med Chem Lett
. 2013 Jun;
23(14):4253-7.
PMID: 23743278
We recently reported the systematic ligand-based rational design and synthesis of monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Expanded structure-activity relationship (SAR)...
10.
Vamos M, Welsh K, Finlay D, Lee P, Mace P, Snipas S, et al.
ACS Chem Biol
. 2013 Jan;
8(4):725-32.
PMID: 23323685
A series of novel, potent antagonists of the inhibitor of apoptosis proteins (IAPs) were synthesized in a highly convergent and rapid fashion (≤6 steps) using the Ugi four-component reaction as...