Michel Weiwer
Overview
Explore the profile of Michel Weiwer including associated specialties, affiliations and a list of published articles.
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27
Citations
567
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Recent Articles
1.
Kabi M, Khamamkar A, Kyei-Baffour K, Weiwer M, Vijayaraghavan S, Dey S
Andrology
. 2025 Jan;
PMID: 39748754
Background And Objectives: Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in...
2.
Placzek M, Wilton D, Weiwer M, Manter M, Reid S, Meyer C, et al.
ACS Cent Sci
. 2024 May;
10(5):1105-1114.
PMID: 38799654
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous system (CNS), COX-2 is implicated in neurodegenerative...
3.
Zhang Y, Moran S, Allen A, Baez-Nieto D, Xu Q, Wang L, et al.
ACS Pharmacol Transl Sci
. 2022 Mar;
5(3):156-168.
PMID: 35311021
T-type voltage-gated Ca channels have been implicated in many human disorders, and there has been increasing interest in developing highly selective and potent T-type Ca channel modulators for potential clinical...
4.
Wagner F, Benajiba L, Campbell A, Weiwer M, Sacher J, Gale J, et al.
Sci Transl Med
. 2018 Mar;
10(431).
PMID: 29515000
Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the wingless-type MMTV integration site family (WNT) pathway, is a therapeutic target of interest in many diseases. Although dual GSK3α/β...
5.
Weiwer M, Xu Q, Gale J, Lewis M, Campbell A, Schroeder F, et al.
ACS Chem Biol
. 2018 Feb;
13(4):1038-1047.
PMID: 29485852
Schizophrenia is a severe neuropsychiatric disease that lacks completely effective and safe therapies. As a polygenic disorder, genetic studies have only started to shed light on its complex etiology. To...
6.
Wagner F, Weiwer M, Steinbacher S, Schomburg A, Reinemer P, Gale J, et al.
Bioorg Med Chem
. 2016 Jul;
24(18):4008-4015.
PMID: 27377864
The structure-activity and structure-kinetic relationships of a series of novel and selective ortho-aminoanilide inhibitors of histone deacetylases (HDACs) 1 and 2 are described. Different kinetic and thermodynamic selectivity profiles were...
7.
Wagner F, Bishop J, Gale J, Shi X, Walk M, Ketterman J, et al.
ACS Chem Biol
. 2016 Apr;
11(7):1952-63.
PMID: 27128528
The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3) and indirectly by increasing GSK3's...
8.
Weiwer M, Chen C, Kemp M, Linhardt R
European J Org Chem
. 2013 Nov;
2009(16).
PMID: 24223493
α-Sialic acid azide has been used as a substrate for the efficient preparation of 1,2,3-triazole derivatives of sialic acid using the copper-catalyzed azide-alkyne Huisgen cycloaddition ("click chemistry"). Our approach is...
9.
Wagner F, Weiwer M, Lewis M, Holson E
Neurotherapeutics
. 2013 Oct;
10(4):589-604.
PMID: 24101253
Lysine acetylation is an ancient, evolutionarily conserved, reversible post-translational modification. A multitude of diverse cellular functions are regulated by this dynamic modification, including energy and metabolism, protein folding, transcription, and...
10.
Weiwer M, Lewis M, Wagner F, Holson E
Future Med Chem
. 2013 Sep;
5(13):1491-508.
PMID: 24024943
Increasing evidence supports a role for epigenetic involvement in some of the neurobiological alterations observed in neurodegenerative and psychiatric disorders including schizophrenia. In particular, there is mounting evidence implicating dysfunction...