Michel L Tremblay
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Explore the profile of Michel L Tremblay including associated specialties, affiliations and a list of published articles.
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175
Citations
5278
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Recent Articles
1.
Spalinger M, Sanati G, Chatterjee P, Hai R, Li J, Santos A, et al.
Cell Mol Gastroenterol Hepatol
. 2025 Jan;
19(5):101447.
PMID: 39756517
Background & Aims: Coronavirus disease (COVID-19), caused by severe acquired respiratory syndrome-Coronavirus-2 (SARS-CoV-2), triggered a global pandemic with severe medical and socioeconomic consequences. Although fatality rates are higher among the...
2.
Colalillo B, Sali S, Aldouhki A, Aubry I, Di Marco S, Tremblay M, et al.
Cell Death Discov
. 2024 Dec;
10(1):503.
PMID: 39695179
The RNA-binding protein HuR regulates various cellular processes, such as proliferation, differentiation, and cell fate. Moreover, recent studies have shown that HuR modulates the expression of factors important for tumor...
3.
Liu Y, Li S, Robertson R, Granet J, Aubry I, Filippelli R, et al.
Life Sci Alliance
. 2024 Oct;
8(1).
PMID: 39477543
Duchenne muscular dystrophy (DMD) is a lethal disease caused by mutations in the gene that encodes dystrophin. Dystrophin deficiency also impacts muscle stem cells (MuSCs), resulting in impaired asymmetric stem...
4.
Gu Y, Taifour T, Bui T, Zuo D, Pacis A, Poirier A, et al.
Nat Commun
. 2024 Oct;
15(1):9174.
PMID: 39448577
Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes. In this study, we identify tumor...
5.
Poirier A, Picard C, Labonte A, Aubry I, Auld D, Zetterberg H, et al.
Sci Rep
. 2024 Jun;
14(1):14718.
PMID: 38926456
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer's disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of...
6.
Chouleur T, Emanuelli A, Souleyreau W, Derieppe M, Leboucq T, Hardy S, et al.
Cancer Res Commun
. 2024 Jun;
4(7):1702-1714.
PMID: 38904264
Significance: High levels of PTP4A2 are associated with poor outcomes in patients with glioma and in mouse models. PTP4A2 depletion increases apoptosis and proinflammatory signals in GBM xenograft models, significantly...
7.
Poirier A, Picard C, Labonte A, Aubry I, Auld D, Zetterberg H, et al.
bioRxiv
. 2024 May;
PMID: 38766183
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer's disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of...
8.
Perez-Quintero L, Abidin B, Tremblay M
Front Med (Lausanne)
. 2024 May;
11:1364778.
PMID: 38707187
In the context of inflammation, T cell activation occurs by the concerted signals of the T cell receptor (TCR), co-stimulatory receptors ligation, and a pro-inflammatory cytokine microenvironment. Fine-tuning these signals...
9.
Gagnon B, Murphy J, Simonyan D, Penafuerte C, Sirois J, Chasen M, et al.
J Cachexia Sarcopenia Muscle
. 2024 Mar;
15(3):1041-1053.
PMID: 38481033
Background: The interdependence of cytokines and appetite-modifying hormones implicated in cancer anorexia-cachexia syndrome (CACS) remains unclear. This study aimed to regroup these cytokines and hormones into distinct inflammatory (or non-inflammatory)...
10.
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation
Poirier A, Ormonde J, Aubry I, Abidin B, Feng C, Martinez-Cordova Z, et al.
Sci Signal
. 2024 Jan;
17(817):eadg4422.
PMID: 38166031
Thousand-and-one-amino acid kinase 3 (TAOK3) is a serine and threonine kinase that belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling and increases the...